Soft capsule and capsule shell composition containing combined antioxidants, capsule shell and soft capsule therefrom and a preparation method thereof

A technology of antioxidants and compositions, applied in the direction of active ingredients of hydroxyl compounds, medical preparations containing active ingredients, capsule delivery, etc., to achieve the effect of improving stability

Active Publication Date: 2011-01-26
SHANDONG DYNE MARINE BIOTECHCAL PHARM HLDG CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The soft capsules currently on the market, especially vitamin AD soft capsules, still cannot solve the above-mentioned ubiquitous stability problems of disintegration and dissolution delay.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0032] The present invention is further described below by way of embodiment, so that better understanding characteristics of the present invention. However, the scope of the present invention is not limited to these Examples. All reagents are commercially available unless otherwise noted.

[0033] Through the following preparation steps, according to the prescription in Table 1, taking vitamins A and D as examples, 9 kinds of vitamin AD soft capsules with different capsule skins were prepared.

[0034] Table 1: Composition of different vesicular compositions

[0035] Element

[0036] Preparation steps:

[0037] According to the above prescription, soft capsules are prepared according to the following steps with the content of 0.3g / capsule and the capsule skin composition of 0.2g / granule. For each formula, gelatin was taken respectively, and an appropriate amount of water was added to make the gelatin absorb water and swell. In addition, other ingredients except g...

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PUM

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Abstract

The invention provides a soft capsule and capsule shell composition containing combined antioxidants. The composition comprises a combination containing certain amount of antioxidants L-lysine and fumaric acid mixed in a certain ratio, and the combination obviously delays the aging progress of the capsule shell prepared from the composition. The invention also provides a soft capsule prepared from the capsule shell and a preparation method thereof.

Description

technical field [0001] The invention generally relates to a soft capsule skin composition containing combined antioxidants, a capsule skin prepared therefrom, a soft capsule and a method for preparing them, and belongs to the technical field of pharmaceutical preparations. Background technique [0002] At present, the soft capsule products on the market, no matter whether the content is water-based, vegetable oil or emulsion, etc., generally have the stability problem of disintegration and delayed dissolution during the long-term storage process. The disintegration of soft capsules and delayed dissolution will lead to the release of drugs. , Delayed absorption, thus affecting the bioavailability and efficacy of the drug. The delay in disintegration and dissolution is mainly caused by the properties of gelatin, the main component of the soft capsule skin. Gelatin is prone to aging during long-term storage. Various factors can lead to aging of gelatin, and oxidation is an impo...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K47/16A61K47/12A61K31/59A61K31/07
Inventor 刘长涛王建村陈伟
Owner SHANDONG DYNE MARINE BIOTECHCAL PHARM HLDG CO LTD
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