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Medicament for treating vascular dementia and preparation method

A technology for vascular dementia and drugs, applied in drug combinations, medical formulas, medical preparations containing active ingredients, etc., can solve the problems of not being able to increase the application of drugs for promoting blood circulation and removing blood stasis, easily damaging righteousness, and affecting the spleen and stomach, etc., to achieve Increase the effect of promoting blood circulation, removing blood stasis, dredging collaterals, and invigorating Yang Qi

Active Publication Date: 2011-01-26
QIANFOSHAN HOSPITAL OF SHANDONG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These drugs, because of the use of a variety of drugs for promoting blood circulation and removing blood stasis, take them for a long time, easily damage the righteousness and affect the spleen and stomach, making them even less able to increase the application of drugs for promoting blood circulation and removing blood stasis

Method used

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  • Medicament for treating vascular dementia and preparation method
  • Medicament for treating vascular dementia and preparation method
  • Medicament for treating vascular dementia and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] Example 1 Preparation of a medicine for treating vascular dementia

[0060] The formula is: Polygonum multiflorum 500g, Yizhi 300g, Astragalus 350g, Gastrodia 250g, Danshen 350g, Leech 180g, Earthworm 250g, Polygala 200g, Ginkgo biloba extract 20g, and Ligusticum chuanxiong 300g.

[0061] The preparation method is:

[0062] (1) Mix the Polygonum multiflorum, Salvia miltiorrhiza, and leeches, add 8 times the amount of 85% ethanol and reflux for 3 hours, filter, and then add 6 times the amount of ethanol with the same concentration to extract the dregs twice, 2 hours each time, filter, Combine the three alcohol extracts, concentrate under reduced pressure to a thick paste with a density of 1.30-1.35, and set aside;

[0063] (2) Mix Ligusticum chuanxiong and Yizhi, add 8 times the amount of water, distill to extract the volatile oil, β-CD inclusion, drying, pulverization, to obtain β-CD inclusion compound, for use; filter out the water for use.

[0064] (3) Combine the dregs of ste...

Embodiment 2

[0066] Example 2 Preparation of a medicine for treating vascular dementia

[0067] The formula is: Polygonum multiflorum 480g, Yizhi 320g, Astragalus 320g, Gastrodia 270g, Danshen 320g, Leech 200g, Earthworm 230g, Polygala 220g, Ginkgo biloba extract 18g, and Ligusticum chuanxiong 320g.

[0068] The preparation method is:

[0069] (1) Mix the prepared Polygonum multiflorum, Salvia miltiorrhiza and leeches, add 2 times the amount of 85% ethanol and reflux for 4 hours, filter, and then add 3 times the amount of ethanol with the same concentration to extract the dregs twice, 3 hours each time, filter, Combine the three alcohol extracts, concentrate under reduced pressure to a thick paste with a density of 1.30-1.35, and set aside;

[0070] (2) Mix Ligusticum chuanxiong and Yizhi, add 2 times the amount of water, distill to extract the volatile oil, β-CD inclusion, drying, pulverization, to obtain β-CD inclusion compound, standby; filter out the water liquid, standby.

[0071] (3) Combine ...

Embodiment 3

[0073] Example 3 Preparation of a medicine for treating vascular dementia

[0074] The formula is: Polygonum multiflorum 520g, Yizhi 280g, Astragalus 380g, Gastrodia 230g, Danshen 380g, Leech 160g, Earthworm 270g, Polygala 170g, Ginkgo biloba extract 22g, and Ligusticum chuanxiong 280g.

[0075] The preparation method is:

[0076] (1) Mix Polygonum multiflorum, Salvia miltiorrhiza with leeches, add 10 times the amount of 85% ethanol and reflux for 1 hour, filter, and add 9 times the amount of ethanol with the same concentration to extract the dregs twice, 1 hour each time, filter, Combine the three alcohol extracts, concentrate under reduced pressure to a thick paste with a density of 1.30-1.35, and set aside;

[0077] (2) Mix Ligusticum chuanxiong and Yizhi, add 10 times the amount of water, distill to extract the volatile oil, β-CD inclusion, drying, pulverization, to obtain β-CD inclusion compound, for use; filter out the water for use.

[0078] (3) Combine the medicinal residues of...

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Abstract

The invention discloses a medicament for treating vascular dementia. The medicament is prepared from the following raw materials in part by weight: 300 to 700 parts of tuber fleeceflower root, 100 to 500 parts of alpinia oxyphylla, 150 to 550 parts of astragalus, 100 to 400 parts of tall gastrodia tuber, 150 to 550 parts of root of red-rooted salvia, 10 to 380 parts of leech, 100 to 400 parts of earthworm, 20 to 400 parts of polygala tenuifolia, 1 to 100 parts of ginkgo leaf extract and 100 to 500 parts of Szechuan lovage rhizome. The Chinese medicinal preparation of the invention has the effects of tonifying kidney, replenishing essence, dissolving blood stasis, promoting the restoration of consciousness and the like, and mainly treats the vascular dementia.

Description

Technical field [0001] The invention relates to a medicine for treating vascular dementia and a preparation method thereof. Background technique [0002] Vascular dementia (VD) is a clinical syndrome of intellectual and cognitive dysfunction caused by cerebrovascular diseases. It is a frequently-occurring and difficult disease in the elderly. It belongs to the categories of "dementia", "amnesia", "stagnation", "textual dementia", and "diness syndrome" of Chinese medicine; its clinical manifestations include a series of abnormal neuropsychological symptoms in addition to the symptoms and signs of damage to the nervous system And mental behavior has become the second largest dementia disease after Alzheimer's disease (AD). Studies have shown that the incidence of VD in Western countries accounts for 15-20% of all dementias. According to my country's dementia epidemiological statistics, with the aging of the population and changes in diet, the incidence is increasing. However, VD ...

Claims

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Application Information

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IPC IPC(8): A61K36/9062A61P25/28A61K35/62A61K35/64
Inventor 李长生杨晓妮李雪云陈超
Owner QIANFOSHAN HOSPITAL OF SHANDONG
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