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Method for detecting Jinze coronary disease capsules

A detection method and technology of Guanxin Capsule, which can be used in measurement devices, pharmaceutical formulations, cardiovascular system diseases, etc., and can solve problems such as difficulty in controlling product quality.

Inactive Publication Date: 2011-02-23
SICHUAN FENGCHUN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The object of the present invention is to provide a quality detection method for Jinze Guanxin Capsules. The present invention aims at the shortcomings of existing quality control standards that are simple and the product quality is difficult to control. Technology, research and customize specific and feasible identification and content determination methods to effectively control the quality of Jinze Guanxin Capsules, so as to ensure the clinical efficacy of the preparation

Method used

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  • Method for detecting Jinze coronary disease capsules
  • Method for detecting Jinze coronary disease capsules
  • Method for detecting Jinze coronary disease capsules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0089] Embodiment 1: the detection method of Jinze Guanxin capsule

[0090] Properties: This product is a capsule, the content is light brown particles; bitter taste;

[0091] Identification of the components of Alisma: take 1 capsule of this product, grind it finely, add 10ml of methanol, ultrasonicate for 15 minutes, filter, evaporate the filtrate to dryness, add 2ml of methanol to dissolve, filter, and use the filtrate as the test solution. Purging 2g of reference medicinal material, add 20ml of methanol, sonicate for 15 minutes, filter, evaporate the filtrate to dryness, add 2ml of methanol to dissolve, filter, and use the filtrate as the reference medicinal material solution, according to Chinese Pharmacopoeia 2010 Edition Appendix VI B thin-layer chromatography , absorb 5 μl of each of the above two solutions, respectively spot on the same silica gel G thin-layer plate with sodium carboxymethylcellulose as the adhesive, use n-hexane: ethyl acetate = 6:1 as the developer,...

Embodiment 2

[0096] Embodiment 2: the detection method of Jinze Guanxin capsule

[0097] Properties: This product is a capsule, the content is light brown particles; bitter taste;

[0098] Identification of the components of Alisma: take 1 capsule of this product, grind it finely, add 10ml of methanol, ultrasonicate for 15 minutes, filter, evaporate the filtrate to dryness, add 2ml of methanol to dissolve, filter, and use the filtrate as the test solution. Purging 2g of reference medicinal material, add 20ml of methanol, sonicate for 15 minutes, filter, evaporate the filtrate to dryness, add 2ml of methanol to dissolve, filter, and use the filtrate as the reference medicinal material solution, according to Chinese Pharmacopoeia 2010 Edition Appendix VI B thin-layer chromatography , absorb 5 μl of each of the above two solutions, respectively spot on the same silica gel G thin-layer plate with sodium carboxymethylcellulose as the adhesive, use n-hexane: ethyl acetate = 6:1 as the developer,...

Embodiment 3

[0102] Embodiment 3: the detection method of Jinze Guanxin capsule

[0103] Properties: This product is a capsule, the content is light brown particles; bitter taste;

[0104] Identification of snow gall ingredients: Take the content of this product, grind it finely, weigh 3.2g, add 20ml of ethyl acetate, put it on a water bath for reflux extraction for 1 hour, filter, concentrate the filtrate to dryness, add 1ml of absolute ethanol to dissolve, and use as For the test solution, take another 2.4g of the reference medicinal material Snow Gallbladder, add 20ml of ethyl acetate, put it on a water bath for reflux extraction for 1 hour, filter, concentrate the filtrate to dryness, add 1ml of absolute ethanol to dissolve, and use it as the reference substance solution. Pharmacopoeia 2010 Edition, Appendix VI B Thin-layer chromatography, draw 10 μl of each of the above two solutions and spot them on the silica gel G thin-layer plate with sodium carboxymethyl cellulose as the binder, ...

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Abstract

The invention provides a method for detecting the quality of Jinze coronary disease capsules. The method comprises part or all items including character, identification, inspection and content determination, wherein the character is required to comply with related regulations on capsules; the ingredient identification is to identify rhizoma alismatis and / or hemsleya amabilis; the inspection is required to comply with all regulations on capsule of A appendix interpretative language (IL) of 'Chinese Pharmacopoeia' of the 2010 version; and the content determination is to determine the alisol B 23-acetate content of the rhizoma alismatis. The quality detection method in the invention has high specificity, high precision, high stability, high repeatability, a high recovery rate and an accurate measuring result, is simple and convenient, improves the quality control standards of the Jinze coronary disease capsules, and can effectively prevent illegal manufacturers from producing the fake Jinze coronary disease capsules and therefore guarantee the clinic curing effects of the preparation.

Description

technical field [0001] The invention relates to a detection method of Jinze Guanxin Capsule medicine, which belongs to the technical field of quality control of medicine. Background technique [0002] Jinze Guanxin Capsule is a variety recorded in the eleventh volume of traditional Chinese medicine preparations in the "Drug Standards of the Ministry of Health". The standard number is WS3-B-2171-96. The prescription is Alisma and Xuedan. It is a capsule of pure Chinese medicine . It has the effects of lowering blood fat, increasing myocardial nutritional blood flow, and reducing myocardial oxygen consumption. It is clinically used for the treatment of coronary heart disease, angina pectoris and hyperlipidemia, and it is a commonly used drug for treating coronary heart disease, angina pectoris and hyperlipidemia in the market. However, the existing Jinze Guanxin Capsules have simple quality control standards, and the product quality is not easy to control. Only the component...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/90A61P3/06A61P9/10G01N30/02A61K36/884
Inventor 钟茂团黎勇温国梁邹波唐终国邓元凤
Owner SICHUAN FENGCHUN PHARMA
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