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Circumferential aerosol device

A kind of equipment and aerosol technology, applied in nebulizers for treatment, other medical devices, inhalers, etc.

Inactive Publication Date: 2011-02-23
UNIV OF WASHINGTON
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] There are currently no suitable nasal delivery devices that adequately target the olfactory area of ​​the nasal cavity while avoiding the lungs and respiratory area of ​​the nasal cavity

Method used

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  • Circumferential aerosol device
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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0071] This example describes figure 1 and 2 examples of different functional parameters of the device.

[0072] The spray rate was tested by varying the drive pressure from 1 to 6 pounds per square inch and varying the diameter of the orifice 154 . The nebulization rate was reproducible and within the desired range for human use, ie less than 50 microliters per second.

[0073] Figure 9 Represents the particle size distribution when water is sprayed from the device into a viscous oil at a distance of 2 cm and 4 psi, the obtained droplet diameters are measured using a microscope with size analysis software. A total of 199 measurements were performed. The distribution indicated that the device produced particles with diameters ranging from 5 to greater than 50 microns, with the majority of particles between 5 and 20 microns in diameter, with an average diameter of 11.2 microns. The size distribution obtained by this method of nebulization is therefore ideal for nasal spray...

example 2

[0081] This example demonstrates the improved penetration of a simulated nose cone with a device including multiple outlets as compared to devices with a single outlet with and without circumferential flow.

[0082] method:

[0083] The flow simulation uses the Star-CCM+ computational fluid dynamics simulation software package (CD-adapco) version 3.06.006. In the simulation, a cone similar to the nasal cavity geometry was used for simplicity. The cone is designed to narrow towards the top with only one outlet at the bottom of the cone for residual air. Thus, the air in the top of the cone is stagnant and must be displaced for the nozzle flow to penetrate the top of the cone, much like the upper nasal cavity of a human. The size of the cone is 7.5 cm from top to bottom to realistically simulate nasal delivery to the human olfactory epithelium.

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Abstract

The present application discloses devices and methods for delivering a therapeutic compound to the olfactory epithelium of an animal or human. The device having one or more channels for imparting a circumferential and axial velocity to the discharged fluid, and an outlet that discharges an aerosol spray having a circumferential and axial velocity as it enters the nasal cavity of a user. The device is designed to displace the air in the upper nasal cavity in order to specifically deposit a therapeutic agent on the olfactory epithelium while minimizing pressure and discomfort experienced by the user.

Description

[0001] Cross References to Related Applications [0002] This application claims priority under 35 U.S.C. 119(e) to U.S. Provisional Patent Application No. 61 / 027002, filed February 7, 2008. [0003] Statement of Government Licensing Rights [0004] This invention was made with US Government support under grant AI052663 from the National Institutes of Health (NIH). The US Government has certain rights in this invention. Background technique [0005] It has been shown that deposition of therapeutic drugs on the olfactory epithelium results in rapid and direct uptake into the brain. This direct nose-to-brain delivery route bypasses the blood-brain barrier which prevents most drugs or drug candidates from reaching the brain in any significant concentration. Many studies, including those of the present inventors, have shown that deposition of drug on the olfactory epithelium while minimizing drug absorption on the respiratory epithelium is essential for maximizing the fraction ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M11/00A61M11/04
CPCA61M15/00A61M15/08A61M2206/14A61M15/009A61M11/06B05B7/0892B05B7/10A61M2206/16A61M31/00
Inventor J·D·霍克曼R·J·Y·霍
Owner UNIV OF WASHINGTON
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