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Melanogenesis inhibitor and skin-whitening agent

A technology of inhibitor and whitening agent, applied in skin care preparations, cosmetic preparations, cosmetic preparations, etc., can solve problems such as unknown melanin effect, and achieve the effect of inhibiting brown spots, strong effect and excellent safety

Inactive Publication Date: 2011-03-23
FUAN KERU
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In addition, the compound of chemical formula (1) is known as an antiviral component, but it is not known whether it has an effect of inhibiting melanin production (Patent Document 3: Japanese Patent Application Laid-Open No. 8-311056)

Method used

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  • Melanogenesis inhibitor and skin-whitening agent
  • Melanogenesis inhibitor and skin-whitening agent
  • Melanogenesis inhibitor and skin-whitening agent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0055] [Melanin Production Inhibition Test]

[0056] For the compound of chemical formula (1), the melanin production inhibitory activity was measured by the following test.

[0057] With the compound of chemical formula (1) as sample, arbutin is used as positive control as sample, hydroxytyrosol, hydroquinone, kojic acid, ascorbic acid 2-glucoside are used as sample as comparison sample, respectively Sulfone was formulated at 10 mg / ml.

[0058] The melanin production inhibitory activity was determined by the following method.

[0059] B16 melanoma F10 derived from mice was inoculated to 20% confluence, and [NLE4, D-PHE7]α-MSH (manufactured by SIGMA-ALDRICH), and the compound of chemical formula (1), arbutin, and hydroxytyrosol were added , hydroquinone, kojic acid, and ascorbic acid 2-glucoside, the concentration of the sample in the culture solution was 1.56 μM to 400 μM. After adding each sample and culturing for 96 hours, the culture solution was removed, and the cells ...

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Abstract

The present invention provides a melanogenesis inhibitor and a skin-whitening agent. Particularly, the invention provides the melanogenesis inhibitor with a chemical formula (1) and the kin-whitening agent thereof.

Description

technical field [0001] The present invention relates to a melanin production inhibitor and a whitening agent. Background technique [0002] Due to air pollution and the destruction of the ozone layer, the amount of ultraviolet rays reaching the epidermis is increasing year by year, and skin troubles such as brown spots, freckles, and darkening of the skin caused by ultraviolet rays are also increasing. Due to ultraviolet rays, tyrosine in the skin is oxidized by tyrosinase to produce melanin pigment, and when it is excessively produced, skin troubles such as brown spots, freckles, and darkening of the complexion will be formed. As a method of inhibiting the production of melanin pigment and preventing brown spots, freckles, and darkening of the complexion, an external preparation for skin containing arbutin (patent document 1: Japanese Patent Application Laid-Open No. 60-16906 ), compounding A skin cosmetic containing L-ascorbic acid and a glucoside of L-ascorbic acid as a ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61P17/00A61K8/49A61Q19/02
CPCA61K8/498A61Q19/02A61K31/353
Inventor 川越大山田昌良
Owner FUAN KERU