Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Complex folic acid/beta-cyclodextrin composite and preparation method thereof

A technology for mixing cyclodextrin and cyclodextrin, which is applied in the directions of pharmaceutical combinations, medical preparations with non-active ingredients, and pharmaceutical formulations to achieve the effects of enhanced stability, stable properties, and avoidance of organic solvent residues

Inactive Publication Date: 2011-04-06
GUANGXI UNIV
View PDF2 Cites 6 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no literature report on the use of cyclodextrin and folic acid to prepare folic acid preparations

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Example 1: Weigh 30.87g of β-cyclodextrin and 4.14g of folic acid in a three-necked flask, add 150mL of distilled water, and stir at a speed of 200r min -1 , Reaction at 80°C for 4h. After the reaction was completed, the reaction solution was left to cool until the yellow solid was fully separated. Filtrate and dry on a fluidized bed to obtain 26.85 g of an inclusion-state folic acid / β-cyclodextrin composition with a yield of 76.7%.

Embodiment 2

[0022] Example 2: Weigh 22.73g of β-cyclodextrin and 5.68g of folic acid into a three-necked flask, add 90mL of distilled water, and stir at a speed of 200r min -1 , Reaction at 90°C for 4h. After the reaction was completed, the reaction solution was left to cool until the yellow solid was fully separated. Filtrate and dry on a fluidized bed to obtain 20.45 g of an inclusion-state folic acid / β-cyclodextrin composition with a yield of 71.97%.

Embodiment 3

[0023] Example 3: Weigh 22.73g of β-cyclodextrin and 4.14g of folic acid into a three-necked flask, add 220mL of distilled water, stir, and the rotation speed is 200r min -1 , Reaction at 60°C for 4h. After the reaction was completed, the reaction solution was left to cool until the yellow solid was fully separated. Filtrate and dry on a fluidized bed to obtain 18.30 g of an inclusion-state folic acid / β-cyclodextrin composition with a yield of 68.12%.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a complex folic acid / beta-cyclodextrin composite and a preparation method thereof. The composite is composed of beta-cyclodextrin and folic acid and the mass ratio of the beta-cyclodextrin to folic acid is 4-7:1. The preparation method comprises the following steps: adding weighted beta-cyclodextrin and folic acid into pure water for mixing to form suspension or solution; under the condition of heating and stirring, standing the reaction solution and cooling the solution until the solid material is sufficiently separated out and filtered; and drying a filter cake after the filtering to obtain the complex folic acid / beta-cyclodextrin composite. The invention has the advantages that the folic acid is embedded in a barrel hollow structure of the beta-cyclodextrin to be the folic acid-beta-cyclodextrin inclusion compound which has obviously enhanced stability, increased solubility and uninfluenced bioactivity; and the active ingredient, namely the folic acid, can be directly applied to foods, medicines and health care products in a clathrate compound mode, thereby overcoming the defects of poor stability, low water-solubility and the like.

Description

technical field [0001] The invention belongs to the technical field of folic acid preparations and preparation methods thereof, in particular to an inclusion state folic acid / beta-cyclodextrin composition and a preparation method thereof. Background technique [0002] Folic acid is a B vitamin composed of pteridine, p-aminobenzoic acid and glutamic acid, also known as vitamin M, which is an essential substance for the growth and reproduction of body cells. Studies have found that folic acid is especially important for pregnant women. During pregnancy, the mother’s demand for folic acid increases, but the intake of folic acid in the body is affected by the decrease of gastric acid secretion and the weakening of gastrointestinal motility. In addition, the excretion of folic acid in urine increases during pregnancy. , It is easy to cause megaloblastic anemia and fetal neural tube defects. [0003] In recent years, domestic and foreign scholars have discovered many new uses of...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/48A61K31/519A61P1/04A61P3/02A61P9/10A61P11/00A61P25/00A61P25/18A61P35/00A61K47/69
Inventor 杨克迪彭盼葛利文衍宣龙云飞李月娟龙丽群宋怡
Owner GUANGXI UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com