Targeting inner ear droplet drug dispenser and use method thereof

Abstract

The invention belongs to the technical field of medical appliances, in particular to a targeting inner ear droplet drug dispenser and a use method thereof. On the basis of the utilization of new material and imageology study, an ultrathin polyimide tube is connected with a micro upgrading injector to realize dispensing drug to the inner ear via the middle ear in the mode of super minimally invasive target. Single dispensing volume in rats is only 2 microlitres and is 10-20 microlitres in the human body. The live animal magnetic resonance imaging research proves that the drug can be dispensed to the inner ear by the product of the invention within half an hour and is evenly distributed on the cochlea after 3 hours, and a minimum quantity of drug is distributed in the non-curative areas, such as the middle ear and the like. Therefore, the targeting inner ear droplet drug dispenser can furthest reduce side effect caused by non-specific distribution of drug at the same time of achieving a treatment effect. The invention is superior to the market product and is an inner ear drug dispenser with the brand-new concept.

Description

technical field [0001] The invention belongs to the technical field of medical devices, and in particular relates to an inner ear drop drug dispenser and a method for using the same. Background technique [0002] Drug delivery to the inner ear via intratympanic injection is considered to be the most minimally invasive way to deliver drugs to the inner ear so far, reducing the side effects of drugs by limiting the distribution of drugs to other parts of the body. However, the dose of drug absorbed through the middle ear mucosa and swallowed through the Eustachian tube drainage is much higher than the amount that enters the inner ear. The pharmacokinetics of the inner ear require continuous drug delivery, and direct injection through the tympanic membrane is not practical. Therefore, a specially designed device for drug delivery to the inner ear through the round window: the Silverstein MicroWick device in the United States is on the market. However, the diameter of the devi...

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Problems solved by technology

However, the diameter of the device is very thick, and it needs to be installed and used through the middle ear ventilation tube. The trauma is large, and it is easy to cause infection, and the injection volume is large, so the side effects caused by the absorption of the above non-target parts cannot be avoided.

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