Preparation technology of nano arsenic trioxide/poly (lactic-co-glycolic acid) coated bracket

A technology of lactic acid glycolic acid copolymer and lactic acid glycolic acid, applied in medical science, surgery, etc., can solve problems affecting the long-term efficacy of PTA

Inactive Publication Date: 2013-12-25
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Since Gruzentig completed the first case of percutaneous transluminal coronary angioplasty (PTCA) in 1977, percutaneous transluminal angioplasty (PTA) has become the primary method to solve vascular occlusive diseases, but there are still 30- Restenosis occurs in 50% of patients, which affects the long-term efficacy of PTA

Method used

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  • Preparation technology of nano arsenic trioxide/poly (lactic-co-glycolic acid) coated bracket
  • Preparation technology of nano arsenic trioxide/poly (lactic-co-glycolic acid) coated bracket
  • Preparation technology of nano arsenic trioxide/poly (lactic-co-glycolic acid) coated bracket

Examples

Experimental program
Comparison scheme
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Embodiment 1

[0056] A nano-arsenic trioxide / lactide-glycolic acid copolymer coated stent comprises: a stent body, and the outside of the stent body is coated with nano-arsenic trioxide / lactide-glycolic acid copolymer.

Embodiment 2

[0058] A kind of preparation method of nano arsenic trioxide / lactic acid glycolic acid copolymer coating stent,

[0059] Preparation of step 1 nano arsenic trioxide / lactic acid glycolic acid copolymer:

[0060] Take 0.01-0.03g of arsenic trioxide powder and fully dissolve it in a sodium hydroxide solution with a molar concentration of 1mmol / L, and adjust the pH value to 7.2-7.4 with 1mmol / L hydrochloric acid to form a liquid;

[0061] Dissolve 100mg of lactic acid-glycolic acid copolymer in 2ml of dichloromethane to form liquid B;

[0062] Add liquid A into liquid B, wherein the volume ratio of liquid A to liquid B is 6-10:1, this embodiment can choose 6:1, 7:1 or 10:1, ultrasonic emulsification for 1 min to form liquid C;

[0063] Add 12ml of polyvinyl alcohol with a mass percentage concentration of 2.25% to 60-100ml of liquid C, use an ultrasonic generator to ultrasonicate liquid C for 90 seconds, disperse in ice water, and form liquid D, among which, the model of the ultra...

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Abstract

A nano arsenic trioxide / poly (lactic-co-glycolic acid) coated bracket comprises a bracket body which is coated by a nano arsenic trioxide coating. The preparation method comprises: a certain amount of arsenic trioxide powder is fully dissolved in a sodium hydroxide solution, and the pH value is adjusted to form A solution; a certain amount of poly (lactic-co-glycolic acid) is dissolved in dichloromethane to form B solution; A solution is added to B solution, and the mixed solution is phacoemulsified to form C solution; polyvinyl alcohol is added to C solution to be ultrasonically dispersed in ice water, and D solution forms; D solution is stirred to form nano arsenic trioxide / poly (lactic-co-glycolic acid) colloidal solution, which is E solution; the stainless steel bare metal stent is ultrasonically cleaned, dried, then kept to stand in B solution; after dried the stent is kept to stand in E solution; the stent is kept in an oven to be dried after the E solution is removed, and the nano arsenic trioxide / poly (lactic-co-glycolic acid) coating stent forms at last.

Description

technical field [0001] The invention relates to an anti-restenosis coating stent and a preparation process thereof, in particular to a nano-arsenic trioxide / lactic acid glycolic acid copolymer coating stent and a preparation process thereof. Background technique [0002] With the change of people's lifestyle and the extension of average life expectancy, the incidence of cardiovascular and cerebrovascular and peripheral vascular occlusive diseases has increased significantly. Since Gruzentig completed the first case of percutaneous transluminal coronary angioplasty (PTCA) in 1977, percutaneous transluminal angioplasty (PTA) has become the primary method to solve vascular occlusive diseases, but there are still 30- Restenosis occurred in 50% of patients, which affected the long-term efficacy of PTA. Later, endoluminal stenting was used to effectively solve the vascular retraction and vascular remodeling after PTA, and the restenosis rate dropped to about 18%. The mechanism o...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/06A61L31/16
Inventor 张东生赵苏苏
Owner SOUTHEAST UNIV
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