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Use of cyclolignans for the treatment of a hyperactive immune system

A technology for immune system and purpose, applied in the direction of digestive system, respiratory system diseases, nervous system diseases, etc., can solve problems such as lack of treatment methods

Inactive Publication Date: 2011-06-01
AXELAR
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] Despite widespread availability of analgesics, nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids, disease-modifying drugs, and immunosuppressants, effective treatments for many of the above conditions still lack

Method used

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  • Use of cyclolignans for the treatment of a hyperactive immune system
  • Use of cyclolignans for the treatment of a hyperactive immune system
  • Use of cyclolignans for the treatment of a hyperactive immune system

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Embodiment Construction

[0032] One aspect of the present invention is to provide the use of the compound of formula I and its pharmaceutically acceptable salts in the preparation of drugs for preventing or treating hyperactivity of the immune system,

[0033]

[0034] where R 1 selected from H, OH and ester groups, and R 2 is selected from O and two H, wherein the five-membered ring is in the cis configuration with two beta bonds.

[0035] Especially, above-mentioned formula I compound can be used for the preparation prevention or treatment at least one is selected from the medicine of following disease: rheumatoid arthritis, Crohn's disease, ulcerative colitis, multiple sclerosis, Alzheimer's disease disease, asthma, eczematous dermatitis, and graft rejection after transplantation.

[0036] As shown in structural formula I, when R 2 When it is O, there is a double bond connecting O to the C atom of the five-membered ring. When R 2 When it is two H, each H is connected to the C atom on the fi...

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PUM

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Abstract

There is disclosed use of certain picro derivatives of cyclolignans for prophylaxis or treatment of diseases or conditions characterised by a hyperactive immune system. Examples of cyclolignans according to the invention include picropodophyllin, deoxypicropodophyllin, anhydropicropodophyllol or deoxyanhydropicropodophyllol.

Description

technical field [0001] The present invention relates to specific cyclolignans for use in the prophylaxis and / or treatment of conditions characterized by hyperactivity of the immune system. Background of the invention [0002] After millions of years of evolution, the human immune system has formed a mature defense mechanism to protect itself from microorganisms and their pathogenic factors. The immune system can be divided into two parts. The first part is the innate or ancient immune system, which includes natural killer (NK) cells lymphocytes, monocytes / macrophages, dendritic cells, neutrophils, basophils, eosinophils, tissue Mast cells and epithelial cells, the immune system can recognize pathogens such as bacteria and can trigger various pathogen clearance mechanisms. The second part is the adaptive immune system, which is a more recently evolved immune response system mediated by T lymphocytes and B lymphocytes. T cells are thymus-derived lymphocytes that regulate ad...

Claims

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Application Information

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IPC IPC(8): A61K31/365A61P1/00A61P11/06A61P17/00A61P19/02A61P25/28A61P37/00
CPCA61K31/365A61K45/06A61P1/00A61P1/04A61P11/06A61P17/00A61P19/02A61P25/00A61P25/28A61P29/00A61P37/00A61P37/06A61K2300/00
Inventor 马格纳斯·阿克塞尔森奥尔·拉森
Owner AXELAR
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