Chlorambucil/layered double hydroxides nano-hybrid and preparation method thereof

A chlorambucil and nano-hybrid technology, which is applied in the preparation of oxides/hydroxides, pharmaceutical formulations, drug combinations, etc., can solve problems such as serious toxic side effects, nervous system damage, etc., to reduce toxic side effects, reduce Drug toxicity and side effects, simple process effect
CN102125697AInactive Publication Date: 2011-07-20QINGDAO UNIV OF SCI & TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
QINGDAO UNIV OF SCI & TECH
Publication Date
2011-07-20
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to chlorambucil / layered double hydroxides (LDHs) nano-hybrid and a preparation method thereof. The chlorambucil / LDHs nano-hybrid prepared by taking LDHs as a carrier is used for controlled release of chlorambucil to improve pesticide effect and reduce toxic and adverse effects of medicament. The chlorambucil / LDHs nano-hybrid is prepared by taking the LDHs as a main body and chlorambucil as an intercalation object by assembling chlorambucil into layers of LDHs through ion exchange process. The hybrid provided by the invention has good effect of slow release of chlorambucil; the adopted preparation method has simple process and mild reaction; and the structure, composition and release rate of the chlorambucil / LDHs nano-hybrid can be realized through changing the synthesis conditions of the chlorambucil / LDHs, such as medicament concentration, synthesis temperature, aging time and other factors.
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Description

technical field

[0001] The invention belongs to the technical field of materials and pharmaceutical preparations, and relates to a chlorambucil / layered double metal hydroxide (LDHs) nano hybrid and a preparation method thereof. Background technique

[0002] With the development of science and the advancement of science and technology, people's requirements for the treatment effect and treatment methods of diseases are increasing day by day. How to improve the curative effect, simplify the way of medication, and reduce the toxic and side effects of drugs is the research focus of scientific and technological workers. Especially for highly toxic drugs, in order to facilitate patients to take them, while ensuring the effective therapeutic concentration, reduce the toxic and side effects of drugs, and avoid the emergence of drug resistance, the effective delivery and controlled release of drugs is undoubtedly an effective method. way. In this effective approach, the development...

Claims

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