Application of miR-21 to preparing medicines for promoting healing of skin injury

A mir-21, 1.mir-21 technology, applied in drug combination, skin disease, pharmaceutical formulation, etc.
CN102166363AInactive Publication Date: 2011-08-31ARMY MEDICAL UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
ARMY MEDICAL UNIV
Publication Date
2011-08-31
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to an application of miR-21 to preparing medicines for promoting healing of skin injury, which belongs to the field of biological medicines, and the miR-21 can effectively promote the healing of skin injury. The miR-21 provided by the invention can be constitutively expressed in a normal skin, and has obviously increased expression in an injured skin. An antisense miR-21 with the function of antagonizing miR-21 can significantly inhibit the healing of skin injury, which indicates that the miR-21 can effectively promote the healing of skin injury.
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Description

technical field

[0001] The present invention relates to the application of non-coding RNA gene miR-21, in particular to the application of miR-21 in the preparation of medicines for promoting skin wound healing, especially the application of miR-21 in the preparation of medicines for promoting skin wound healing. technical background

[0002] Fibroblasts are the main functional cells in the process of wound healing and have heterogeneity. During vertebrate wound healing, if dermal fibroblasts can be activated, scarless healing may occur. During epithelial regeneration, no hair grows, and the same is true during sweat gland regeneration. In fetal wound healing, fibroblasts of dermis-related tissues can receive permission signals to develop into different types of hair follicles at corresponding locations, and can also differentiate and regenerate other skin appendages. TGF-β is involved in the whole process of skin healing after trauma. TGF-β can chemoattract and act on fi...

Claims

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