Muramidase hydrolase external sterile cream for treating skin ulcer and preparation method thereof

A technology of lysozyme hydrochloride and skin ulcers, which is applied in the field of medicine, can solve the problems of ulcer surface harm, secondary bacterial infection, and wound surface difficult to heal

Active Publication Date: 2011-09-14
SHANDONG SBOND PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

If the raw materials, auxiliary materials and production conditions used in the preparation are not sterilized or the sterilization method is improper, it is easy to cause secondary infection in clinical practice, making it more difficult to heal the wound surface, resulting in unsatisfactory treatment effect or greater da

Method used

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  • Muramidase hydrolase external sterile cream for treating skin ulcer and preparation method thereof
  • Muramidase hydrolase external sterile cream for treating skin ulcer and preparation method thereof
  • Muramidase hydrolase external sterile cream for treating skin ulcer and preparation method thereof

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Embodiment Construction

[0014] A lysozyme hydrochloride sterile cream for external use for treating skin ulcers, the mass parts of raw materials include the following components:

[0015] A: 50-80 parts of lysozyme hydrochloride, enzyme activity 6200-20000 units / mg;

[0016] B: 50-80 parts of Span, 30-60 parts of poloxamer, 30-50 parts of Tween, 20-40 parts of sorbitol, 10-20 parts of sodium dihydrogen phosphate, 1-10 parts of ethylparaben;

[0017] C: 220-260 parts of liquid paraffin, 30-50 parts of glyceryl monostearate, 10-30 parts of cetyl alcohol, 10-30 parts of stearyl alcohol, 70-100 parts of white petrolatum;

[0018] D: 449-500 parts of sterile water.

[0019] According to the present invention, preferably, a kind of lysozyme hydrochloride sterile cream for external use for the treatment of skin ulcers, the mass parts of raw materials include the following components:

[0020] A: 50-60 parts of lysozyme hydrochloride, the enzyme activity is 12000-16000 units / mg;

[0021] B: Span-4050-60 p...

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Abstract

The invention discloses a muramidase hydrolase external sterile cream for treating skin ulcer and a preparation method thereof. The muramidase hydrolase external sterile cream is prepared from the following raw materials of: muramidase hydrolase, Span, poloxamer, Tween, sorbierite, sodium dihydrogen phosphate, ethylparaben, liquid paraffin, glycerin monostearate, cetyl alcohol, stearyl alcohol, albolene and sterile water. The invention also provides a preparation method for the muramidase hydrolase external sterile cream. The preparation method comprises the following steps of: dissolving; performing high temperature sterilization; filtering and removing bacteria by using a filter membrane; homogenizing at a low speed; homogenizing at a high speed; stirring; reducing temperature; and performing sterile filling. The muramidase hydrolase external sterile cream is used for treating the skin ulcer including bedsore, burn ulcer, calf ulcer, post-zoster ulcer, diabetic ulcer and postoperative ulcer in a transdermal administration form.

Description

technical field [0001] The invention relates to a sterile cream for external use of lysozyme hydrochloride for treating skin ulcers (bedsores, scald ulcers, calf ulcers, postherpetic ulcers, diabetic ulcers, and postoperative ulcers) and a preparation method thereof, which belong to medical technology field. Background technique [0002] Skin ulcers, including decubitus ulcers, burn ulcers, calf ulcers, postherpetic ulcers, diabetic ulcers, and postoperative ulcers, refer to localized defects formed by local skin or adhesive necrosis, disintegration, and shedding. [0003] In my country, skin ulcers and decubitus diseases are common and frequently-occurring diseases. The etiology of skin ulcers and decubitus ulcers is soft tissue necrosis caused by neurotrophic disorders, blood circulation disorders, local tissue continuous ischemia, and malnutrition. If not treated in time, other organ complications may be induced. According to relevant literature reports, the incidence r...

Claims

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Application Information

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IPC IPC(8): A61K38/47A61K9/06A61K47/44A61K47/34A61P17/02A61K47/26
Inventor 乔敏袁武杰
Owner SHANDONG SBOND PHARMA
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