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Manufacturing method of magnetic ball for living being, magnetic ball thereof and magnetic object

A manufacturing method and technology of magnetic balls, applied in the manufacture of biological magnetic balls, biological magnetic balls and magnetic objects

Inactive Publication Date: 2011-09-21
HITACHT MAXELL LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In particular, the inventors of the present application did not deal with limitations and problems in microparticles, microplates, test tubes, etc. by continuing the prior art, but dealt with them from a new point of view, and tried to solve the following problems

Method used

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  • Manufacturing method of magnetic ball for living being, magnetic ball thereof and magnetic object
  • Manufacturing method of magnetic ball for living being, magnetic ball thereof and magnetic object
  • Manufacturing method of magnetic ball for living being, magnetic ball thereof and magnetic object

Examples

Experimental program
Comparison scheme
Effect test

example A

[0134] For example, in the above description, the number of magnetic particles used in the step (i) is "at least two", but it is not necessarily limited thereto. That is, it is also possible to manufacture a magnetic ball using one magnetic particle. In this way, the manufacturing method of the magnetic ball preferably includes:

[0135] (i) a process of mixing one magnetic particle and a resin material to prepare a particle-containing resin material,

[0136] (ii) a step of molding a particle-containing resin raw material to obtain a particle-containing molded product, and

[0137] (iii) A step of grinding and / or grinding the particle-containing molded product into a spherical shape to form magnetic balls with a particle diameter of 0.1 mm to 30 mm.

[0138] The magnetic ball obtained by this production method has a structure containing one magnetic particle in the resin component, and has a structure of 2-200A·m 2 / kg saturation magnetization and 0~10A·m 2 / kg of residua...

example B

[0149] In addition, in the above description, the shape of the magnetic particle is "spherical shape", but it is not limited thereto. That is to say, according to the purpose of use, also can be the following magnetic substance, and even if it is this kind of magnetic substance, also can obtain the same effect as the above-mentioned magnetic ball of the present invention:

[0150] A magnetic substance used in the field of biotechnology and life science, the magnetic substance is formed by a composite in which at least two magnetic particles are dispersed in a resin part, the size of the composite is 0.1 mm to 30 mm, and as The overall saturation magnetization of the magnetic material is 2-200A·m 2 / kg, the residual magnetization is 0~10A·m 2 / kg (where the saturation magnetization value is greater than the residual magnetization value). Even with such a magnetic substance, part or all of its surface may be made of resin, and the surface may have a ground surface or a polishe...

Embodiment

[0184] According to the manufacturing method of the present invention, a magnetic ball is manufactured.

[0185] First, about 5% by weight (about 1% by volume) of magnetic particles (saturation magnetization: 85A·m 2 / kg, residual magnetization: 5.1A m 2 / kg) mixed with polystyrene to obtain a particle-dispersed resin raw material (in addition, the "weight%" and "volume%" of the magnetic particles here are the weight basis and volume basis of the particle-dispersed resin raw material. That is, [weight% =Magnetic particle weight / (Magnetic particle weight+Resin raw material weight)×100] and [Volume%=Magnetic particle volume / (Magnetic particle volume+Resin raw material volume)×100]). Next, the obtained particle-dispersed resin raw material is molded into a substantially spherical shape by injection molding. Next, rough grinding is performed on the molded product, then semi-finishing grinding, buffing grinding (gloss) is performed, and 1,000 to 50,000 pieces are produced. figur...

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Abstract

The present invention provides a manufacturing method of a magnetic ball for living being, a magnetic ball thereof and a magnetic object, wherein the method is a facility for reducing or eliminating restriction and problem that are caused by particles and microplate tube. The manufacturing method is used for manufacturing the magnetic ball which is used in the fields of biotechnology and life science. The manufacturing method comprises the following steps: (i) a step of mixing at least two magnetic particles and a resin material for preparing a particle dispersion resin material; (ii) a step of molding the particle dispersion resin material for obtaining a particle dispersion molded product; and (iii) grinding and / or abrading the particles to a sphere shape for forming the magnetic ball with particle diameter in 0.1mm-30mm. Furthermore, the magnetic ball has a saturated magnetization intensity of 2-200A*m2 / kg and a residual magnetization intensity of 0-10A*m2 / kg (wherein, the saturated magnetization intensity is larger than the residual magnetization intensity).

Description

technical field [0001] The invention relates to a manufacturing method of a biological magnetic ball. More specifically, the present invention relates to a method for manufacturing magnetic balls suitable for separation, immobilization, analysis, extraction, purification, or reaction of target substances. Furthermore, in the present invention, it also relates to a biological magnetic ball and a magnetic object obtained by this manufacturing method. Background technique [0002] Conventionally, various magnetic beads that can be used for extraction, purification, reaction, detection, analysis, or synthesis of trace samples have been sold on the market in the field of biotechnology or life science. These magnetic beads are tiny beads with a particle size ranging from tens of nanometers to several microns. Because of the "smallness", the surface area of ​​the beads increases, which can effectively increase the throughput of target substances and improve the sensitivity of det...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): H01F1/42B22F1/02
Inventor 河野研二臼杵直树满永雅一神崎寿夫
Owner HITACHT MAXELL LTD
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