Pharmaceutical composition for treating pain syndrome or arthralgia syndrome and preparation method and application thereof

A composition and medicine technology, applied in the field of medicine, to achieve the effect of lasting effect and unique curative effect

Inactive Publication Date: 2012-09-19
成都神黄医药科技开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

"There is no clinical report on the combination of curcuma, Sanleng and Zushima to treat arthralgia or pain syndrome

Method used

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  • Pharmaceutical composition for treating pain syndrome or arthralgia syndrome and preparation method and application thereof
  • Pharmaceutical composition for treating pain syndrome or arthralgia syndrome and preparation method and application thereof
  • Pharmaceutical composition for treating pain syndrome or arthralgia syndrome and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] The preparation of embodiment 1 composition rubber ointment of the present invention

[0046] Curcuma 1Kg, Zushima 1Kg, Sanleng 1Kg, rubber 10Kg, menthol 1.8Kg, borneol 1.2Kg, camphor 1.2Kg, lithopone 25Kg, rosin 6Kg, liquid paraffin 0.5Kg.

[0047] Zedoary Curcumae, Zushima and Sanleng of the prescription amount were taken, pulverized, passed through a 16-mesh sieve, mixed, added 10 times the amount (relative to the quality of the raw material drug) 80% ethanol to extract 3 times, each time for 1h, combined the filtrates, and concentrated into an infusion paste; heat the medicinal material extract through a 100-mesh sieve, and set aside; then cut the rubber into blocks of about 3Kg each, and after the rubber machine operates normally, put the blocks into it and refine them into mesh sheets; melt the rosin, Pass through a 100-mesh steel mesh while it is hot, crush it through a 100-mesh sieve after cooling, and set aside; then mix the prepared rubber flakes, mixed rosin po...

Embodiment 2

[0048] The preparation of embodiment 2 compositions cataplasm of the present invention

[0049] The invention discloses a preparation method of a cataplasm of a pharmaceutical composition for treating pain or arthralgia. It adopts low-temperature production, and a water-soluble polymer substance is used as a matrix, thereby preserving the biological activity of the effective substance without any stimulation to the skin. The addition of a transdermal agent greatly enhances drug release and transdermal properties. It is the latest dosage form of an external plaster. Production methods include:

[0050] Prescription: Curcuma 1Kg, Zushima 1Kg, Sanleng 1Kg, Menthol 1.8Kg, Borneol 1.2Kg, Gelatin 3Kg, Sodium Polyacrylate 1.5Kg, Polyvinyl Alcohol 1.2Kg, Kaolin 0.5Kg, Glycerin 6Kg, Castor Oil 1Kg, Carboxylic Sodium methylcellulose 1Kg, sorbitol 0.5Kg. Preparation matrix: Take sodium polyacrylate, polyvinyl alcohol, sodium carboxymethyl cellulose, gelatin, sorbitol and add water to s...

Embodiment 3

[0051] The preparation of embodiment 3 compositions ointment of the present invention

[0052] The invention discloses a preparation method of an ointment of a pharmaceutical composition for treating pain or arthralgia. In the method, a semi-solid external preparation is prepared by mixing Chinese medicinal material extracts with a suitable matrix. Production Method:

[0053] Prescription: Curcuma 1Kg, Zushima 1Kg, Sanleng 1Kg, magnesium sulfate 0.5Kg, dimethyl sulfoxide 0.5Kg, oil-soluble substances 1Kg, water-soluble substances 3Kg (including water 2Kg)

[0054] Zedoary Curcuma, Zushima and Sanleng of the prescribed amount were weighed, pulverized, passed through a 16-mesh sieve, mixed, added 10 times the amount (relative to the quality of the crude drug) 80% ethanol to extract 3 times, each time for 1h, combined filtrates, and concentrated to immersion Ointment, spare. Heat and melt the oil-soluble substance at 80-100°C, dissolve magnesium sulfate, dimethyl sulfoxide, emu...

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Abstract

The invention provides a pharmaceutical composition for treating pain syndromes or arthralgia syndromes, which is a preparation mainly prepared by the following raw herbs by weight: 3-15 parts of zedoary turmeric, 3-15 parts of cirald saphne bark, 3-15 parts of rhizoma sparganii; the preparation has the efficacy of invigorating blood circulation and relieving pain, dispelling wind and removing dampness, relaxing muscles and tendons and activating collaterals, and is mainly used to treat diseases such as pain and swelling in local joints, bones or muscles, rheumatism, rheumatoid diseases and the like caused by qi and blood stasis, and meridian obstruction. The preparation method of the invention combines auxiliary materials of traditional Chinese medicines, menthol, lithopone powder, borneol, and the like which not only have synergistic interaction, but also have no irritation to skin; the pharmaceutical composition of the invention is easy for uncovering and plastering, has the effectof cooling and relieving itching, detumescence and relieving pain, and has unique curative effect, lasting effect, safety and reliability.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating pain syndrome or arthralgia syndrome, which is mainly prepared from curcuma, Zushima, Sanleng and the like as raw materials, and belongs to the field of medicine. Background technique [0002] According to the theory of traditional Chinese medicine, the evil numbness caused by wind-cold, damp-heat blocks the meridians, and the circulation of blood and qi is not smooth, which will lead to numbness for a long time. Arthralgia is clinically characterized by pain, soreness, heaviness, numbness or redness, swelling and burning heat in muscles, muscles, bones and joints, joint swelling, and difficulty in flexion and extension, and is characterized by gradual and recurrent attacks. Rheumatic fever, rheumatoid arthritis, rheumatoid arthritis and various connective tissue diseases in modern medicine all belong to the category of arthralgia in motherland medicine. [0003] Rheumatism refers to d...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9066A61P19/02A61P29/00
Inventor 熊雄何宇新李玲吴丽张康
Owner 成都神黄医药科技开发有限公司
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