Compound Retapamulin medicinal membrane agent and preparation method thereof
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A technology of retamoline and compound Rui, which is applied in antibacterial drugs, pharmaceutical formulations, plant raw materials, etc., can solve the problem of not being used by humans, and achieves relief of wound pain, good anti-infection effect, and good anti-infection effect. Effect
Active Publication Date: 2013-06-12
SHANXI XINYUAN HUAKANG CHEM
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[0002] Pleuromutilin antibiotics are derived from an edible mushroom (Basidiomycetes) in nature, and a large part of them have not been used clinically by humans
Method used
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Embodiment 1
[0040] Prescription: 400 grams of knotweed, 250 grams of coptis, 200 grams of bletilla striata, and 20 grams of retapamulin.
[0041] Crush knotweed, coptis, and bletilla striata into coarse powder, add 12 times of water to soak for about 14 hours, decoct for 1 hour, add 8 times of water for 1 hour, combine the two decoctions, let stand overnight, filter, and collect Concentrate the filtrate to an appropriate amount (about 1000 ml), add preservatives, then add 20 grams of retapamulin, 500 ml of 50% gelatin solution, 100 ml of benzalkonium bromide, add water to adjust the total amount to 2000 ml, mix well, extinguish Bacteria to prepare a compound retapamulin drug film with a retapamulin content of 0.01 g / ml and a traditional Chinese medicine extract content of 0.002 g / ml in terms of active parts.
Embodiment 2
[0043]Prescription: 200 grams of knotweed, 100 grams of coptis, 100 grams of bletilla striata, and 10 grams of retapamulin.
[0044] Crush knotweed, coptis, and bletilla striata into coarse powder, add 1500 ml of water to soak for about 20 hours, decoct for 1 hour, add 1000 ml of water for 2 hours, combine the two decoctions, let stand overnight, filter, and collect the filtrate. Concentrate to an appropriate amount, add preservatives, add 10 grams of retapamulin, 500 ml of 25% gelatin solution, 50 ml of benzalkonium bromide, add water to adjust the total amount to 1000 ml, mix well, and sterilize to make retapamulin Compound retapamulin pharmaceutical film with a forest content of 0.01 g / ml and a Chinese medicine extract content of 0.002 g / ml in terms of active parts.
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Abstract
The invention relates to a compound Retapamulin medicinal membrane agent, which comprises Retapamulin serving as a medicinal active ingredient and a Chinese medicinal extract, wherein each milliliter of membrane agent contains 0.005 to 0.01 gram of Retapamulin and 0.002 to 0.004 gram of active ingredients of Chinese medicinal extract. A preparation method for the Chinese medicinal extract comprises the following steps of: decocting 40 to 60 weight parts of giant knotweed rhizome, 15 to 30 weight parts of golden thread and 5 to 25 weight parts of bletilla which serve as raw materials, and concentrating to obtain the Chinese medicinal extract. The compound Retapamulin medicinal membrane agent is used for treating pustulosis and small-area infectious trauma, and is convenient to use and goodin effect. Clinical test observation indicates that after the membrane agent is used, the pain of wounds of patients is relieved obviously, and the healing time is advanced generally. In addition, the compound Retapamulin medicinal membrane agent also has the advantages of no irritation, no sensitivity, no toxicity to important visceral organs such as hemocyte, liver and kidney and the like.
Description
technical field [0001] The invention relates to an anti-inflammatory medicinal film for external use, in particular to a compound retapamulin medicinal film which uses retapamulin as a main component and is used in conjunction with traditional Chinese medicine. The invention also relates to a preparation method of the medicine film. Background technique [0002] Pleuromutilin antibiotics are derived from an edible mushroom (Basidiomycetes) in nature, and a large part of them have not been used clinically by humans. This class of antibiotics has a unique mechanism of action, which is to inhibit the synthesis of bacterial proteins by binding to the ribosomes of prokaryotes. In the veterinary field, tiamulin and valnemulin are two semi-synthetic isoforms of pleuromutilin, which are used to control and treat severe infections in pigs and poultry. [0003] Retapamulin (SB-275833), the English name Retapamulin, is a semi-synthetic derivative of the pleuromutilin antibiotic isola...
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