The invention provides a skin barrier ointment dressing and a preparation method thereof, comprising the following raw materials in parts by weight: 2-30 parts of β-glucan, 1-15 parts of sodium hyaluronate, 2-15 parts of ceramide, carbomer 5-10 parts, 10-20 parts of polyethylene glycol-400, 3-10 parts of yeast polypeptides, 2-8 parts of glycerin, 2-6 parts of Tween 80, 4-20 parts of ethyl p-hydroxybenzoate, three 3-8 parts of ethanolamine, 0.3-0.8 parts of fish bone essential oil and 200-600 parts of water, the paste dressing of the present invention, its raw materials are all non-toxic natural materials, have excellent biocompatibility, biodegradability and good Excellent air permeability, can absorb a large amount of tissue exudate and have certain water retention performance, and can promote hemostasis and regeneration of native tissue, achieve continuous moisturizing, moisturizing and stable effects of the dressing, and provide a more stable repair screen for wounds closed environment.