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Method for preparing medical antimicrobial dressing

A technology of silver dressing and acetonitrile, which is applied in the fields of medical science, biochemical fiber treatment, absorption pad, etc., can solve the problem that the treatment effect of deep wounds or refractory wounds needs to be improved, and achieves easy enlargement and preparation, strong antibacterial performance, and simple method. easy effect

Inactive Publication Date: 2020-07-24
JILIN UNIV FIRST HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, in the prior art, the therapeutic effect on deep wounds or refractory wounds still needs to be improved.

Method used

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  • Method for preparing medical antimicrobial dressing
  • Method for preparing medical antimicrobial dressing
  • Method for preparing medical antimicrobial dressing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Add 2000mL acetonitrile, 0.1mol sodium hydroxide and 20g medical grade sodium carboxymethylcellulose silver dressing to a 5000mL two-necked flask, add 0.4mol epoxypropyl dimethyl octadecyl ammonium chloride, seal it, and react at 60°C After 24 hours, the sample was taken out, washed with ethanol, dried in a vacuum oven to constant weight, and a new type of medical antibacterial dressing modified by quaternary ammonium salt was obtained.

Embodiment 2

[0036] Add 2000mL acetonitrile, 0.1mol sodium hydroxide and 0.5mol pyridine mixture, 20g medical sodium carboxymethylcellulose silver dressing, add 0.5mol acid chloride dimethyl alkyl ammonium chloride into a 5000mL two-necked flask, seal it, and store it at 30°C After reacting for 48 hours, the sample was taken out, cleaned with ethanol, dried in a vacuum oven to constant weight, and a new type of medical antibacterial dressing modified with quaternary ammonium salt was obtained.

Embodiment 3

[0038] Add 2000mL of acetonitrile, 0.1mol of sodium hydroxide, 0.1mol of pyridine, 0.1mol of sodium carbonate, 0.15mol of hydrochloric acid, 0.15mol of sulfuric acid into a 5000mL two-necked flask, 20g of medical sodium carboxymethylcellulose silver dressing, and add 0.6mol of ester group Dimethyl alkyl ammonium chloride, sealed, reacted at 80°C for 4 hours, cleaned the sample with ethanol, dried in a vacuum oven to constant weight, and obtained a new type of medical antibacterial dressing modified by quaternary ammonium salt.

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Abstract

The invention discloses a method for preparing a medical antimicrobial dressing. The method comprises the steps of adding 0.01-2 mol of a catalyst and 15-30 g of a medical sodium carboxymethyl cellulose silver dressing into an acetonitrile solution; adding 0.1-2 mol of quaternary ammonium salt micromolecules with an active group, sealing the solution and then carrying out grafting reaction at 20-80 DEG C for 1-96 h; and finally taking out the medical sodium carboxymethyl cellulose silver dressing, cleaning the medical sodium carboxymethyl cellulose silver dressing with ethanol and drying the medical sodium carboxymethyl cellulose silver dressing to constant weight in vacuum to obtain a quaternary ammonium salt-modified medical antimicrobial dressing. The problem in treatment of a deep wound or a refractory wound in the prior art is solved.

Description

technical field [0001] The invention belongs to the technical field of antibacterial dressings, and in particular relates to a preparation method of a novel medical antibacterial dressing with high-efficiency antibacterial and water-absorbing properties, which takes medical carboxymethylcellulose sodium silver dressing as a precursor. Background technique [0002] As the largest organ of the human body, the skin not only regulates the metabolism of the body, but also plays an important role in resisting external damage. Because of this, the skin is also extremely vulnerable to burns, lacerations, and non-healing wounds of various causes, which often cause wound infection and delay wound healing. As we all know, wound healing is divided into several stages, including the inflammatory response stage, the granulation tissue formation stage and the scab formation stage. During the wound healing period, it is often disturbed by various factors, and problems in each link will del...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D06M13/463D06M13/345D06M11/38D06M13/355D06M11/76D06M11/11A61L15/18A61L15/20A61L15/28A61L15/42A61L15/46D06M101/08
CPCD06M13/463D06M13/345D06M11/38D06M13/355D06M11/76D06M11/11D06M11/55D06M16/00A61L15/28A61L15/18A61L15/20A61L15/42A61L15/46D06M2101/08A61L2300/204A61L2300/104A61L2300/208C08L1/286
Inventor 周鑫于家傲陈欣欣石凯高欣欣洪雷张修行
Owner JILIN UNIV FIRST HOSPITAL
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