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Double-layer composite drug-loading adhering patch and preparation method and application thereof

A double-layer compounding and medicament technology, which is applied in the field of medical and biomedical materials, can solve the problems of single effect and the inability to form a gradient release of drugs, and achieve the effects of preventing infection, promoting rapid healing, and good treatment

Active Publication Date: 2019-06-21
XI'AN POLYTECHNIC UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to solve the defects in the above-mentioned prior art, the object of the present invention is to provide a double-layer composite drug-loaded adhesive patch and its preparation method and application, The double-layer drug structure combined with the sudden-release drug and the sustained-release drug solves the problem that the current single-layer drug-loaded adhesive patch has a single drug effect and the drug cannot form a gradient release.

Method used

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  • Double-layer composite drug-loading adhering patch and preparation method and application thereof
  • Double-layer composite drug-loading adhering patch and preparation method and application thereof
  • Double-layer composite drug-loading adhering patch and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0045] Step 1: Weigh 1 part of diclofenac sodium and 3 parts of polyethylene oxide and add it to 1800 parts of deionized water, stir on a magnetic stirrer for 24 hours until the mixture becomes a uniform milky white solution, and use it as a spinning solution for burst drug release; weigh Add 0.1 part of curcumin and 10 parts of L-polylactic acid to 100 parts of hexafluoroisopropanol, stir on a magnetic stirrer for 24 hours until the mixture becomes a uniform and transparent yellow solution, and use it as a slow-release drug spinning solution for use;

[0046] Mix 0.001g of hydroxypropyl methylcellulose, 0.01ml of propylene glycol and 0.1ml of deionized water in a syringe to form a homogeneous solution, place it on a centrifuge and centrifuge once at a speed of 1000r / min, remove the bubbles in the solution, and inject plastic The round hole of the silicone mold is ready for use, and the thickness of the mold is 0.5mm.

[0047] Step 2: Under the working environment of 15°C and ...

Embodiment 2

[0051] Step 1: Weigh 5 parts of diclofenac sodium and 20 parts of polyethylene oxide and add them to 3500 parts of deionized water, stir on a magnetic stirrer for 24 hours until the mixture turns into a uniform milky white solution, and use it as a burst drug spinning solution for use; weigh Add 10 parts of curcumin and 100 parts of L-polylactic acid to 500 parts of hexafluoroisopropanol, stir on a magnetic stirrer for 24 hours until the mixture becomes a uniform and transparent yellow solution, and use it as a slow-release drug spinning solution;

[0052] Mix 1g of hydroxypropyl methylcellulose, 1ml of propylene glycol and 5ml of deionized water in a syringe to form a homogeneous solution, place it on a centrifuge and centrifuge 5 times at a speed of 8000r / min, remove the bubbles in the solution, and inject it into a plastic silicone mold. Stand-by in the round hole, the thickness of the mold is 3mm.

[0053] Step 2: Under the working environment of 30°C and 60% relative humi...

Embodiment 3

[0057] Step 1: Weigh 3 parts of diclofenac sodium and 12 parts of polyethylene oxide and add them to 2200 parts of deionized water, stir on a magnetic stirrer for 24 hours until the mixture becomes a uniform milky white solution, and use it as a burst release drug spinning solution for use; weigh Add 3 parts of curcumin and 50 parts of L-polylactic acid to 300 parts of hexafluoroisopropanol, stir on a magnetic stirrer for 24 hours until the mixture becomes a uniform and transparent yellow solution, and use it as a slow-release drug spinning solution;

[0058] Mix 0.1g hydroxypropyl methylcellulose, 1ml propylene glycol and 1ml deionized water in a syringe to form a homogeneous solution, place it on a centrifuge and centrifuge 3 times at a speed of 3000r / min, remove the bubbles in the solution and inject it into a plastic silicone mold The round hole is ready for use, and the thickness of the mold is 1.5mm.

[0059] Step 2: Under the working environment of 20°C and 40% relative...

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Abstract

The invention discloses a double-layer composite drug-loading adhering patch and a preparation method and application thereof and belongs to the technical field of biological medical materials. The preparation method includes: mixing a burst-release drug with high polymer, mixing a sustained-release drug with high polymer, using electrostatic spinning equipment to prepare a burst-release drug layer and a sustained-release drug layer, and compositing the burst-release drug layer and the sustained-release drug layer with an adhering film to obtain the double-layer composite drug-loading adheringpatch. When the double-layer composite drug-loading adhering patch is used, the burst-release drug layer and the sustained-release drug layer can load different types of drugs to form gradient release so as to achieve an optimal curative effect. The double-layer composite drug-loading adhering patch has the advantages that a nanofiber membrane serving as the carrier is high in specific surface area, high in porosity, moisture-permeable and air-permeable, low in fiber diameter, capable of increasing drug loading quantity and the like, the high porosity is beneficial to cell growth and proliferation and can promote the fast healing of wounds, the moisture and air permeability can simulate the natural environment of a mucous membrane or the skin and is beneficial to the neogenesis cell growth of the wounds, and the low fiber diameter can provide more growth loci for the cells and can accelerate wound healing.

Description

technical field [0001] The invention belongs to the technical field of medical and biomedical materials, and in particular relates to a double-layer composite drug-loaded adhesive patch and its preparation method and application. Background technique [0002] Oral ulcers are a common condition in which ulcers occur in the oral mucosa. Abnormal pain can be felt at the ulcer lesion site during the outbreak of oral ulcer, which causes great misery to the patient. At present, there are two ways to treat oral ulcers: one is to achieve the purpose of antibacterial and anti-inflammatory through oral administration, so as to reduce the pain caused by oral ulcers; the other is to directly apply the medicine on the ulcer surface so that the medicine can directly act on the ulcer Part to achieve the purpose of treating oral ulcers. However, these two methods for the treatment of oral ulcers all have their shortcomings: the former is because the oral medicine needs to be digested and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K47/10A61K47/34A61K31/196A61K31/12A61P17/02A61P29/00A61P31/02A61P1/02D04H1/728D04H1/425D01D5/00D01F6/92D01F1/10
Inventor 魏亮孙润军樊威刘呈坤支超苗亚萍
Owner XI'AN POLYTECHNIC UNIVERSITY
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