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Fast dissolving oral tablets and method for production thereof

An oral tablet, rapid technology, applied in the direction of pill delivery, pharmaceutical formula, medical preparations of non-active ingredients, etc., can solve the problems of inapplicability, abnormal size of tablets, etc.

Inactive Publication Date: 2011-10-19
CJ CHEILJEDANG CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method has the advantage that mechanical strength is compensating, but it should only be applied to tablets with a small number of therapeutic components, because excess sugar can be directly tableted or use strong dissolving agents
In addition, this method has the disadvantage that it is not suitable when using high-volume drugs, or if applicable, the tablets form abnormal sizes

Method used

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  • Fast dissolving oral tablets and method for production thereof
  • Fast dissolving oral tablets and method for production thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] A general tablet with a total tablet weight of 100 mg and a hardness of 7 kp was obtained by using 90 mg D-mannitol as a sugar alcohol, 2.5 mg PVR k-30 as a binder, 5 mg cetyl alcohol as a supercritical fluid-soluble substance, and 2.5 mg SiO 2 Made as a lubricant. And then, cetyl alcohol as a supercritical fluid-soluble substance was purified and extracted by contacting the tablet with supercritical fluid at a temperature of 40° C. and a pressure of 80 bar for 30 minutes to produce a fast-dissolving tablet with micropores.

Embodiment 2

[0041] A general tablet with a total tablet weight of 100 mg and a hardness of 7 kp was obtained by using 90 mg D-mannitol as a sugar alcohol, 2.5 mg PVR k-30 as a binder, 5 mg cetyl alcohol as a supercritical fluid-soluble substance, and 2.5 mg SiO 2 Made as a lubricant. And then, cetyl alcohol as a supercritical fluid-soluble substance was purified and extracted by contacting the tablet with supercritical fluid at a temperature of 40° C. and a pressure of 80 bar for 30 minutes to produce a fast-dissolving tablet with micropores. The extraction rate of the supercritical fluid-soluble matter is 50.4%.

Embodiment 3

[0043] The same method as in Example 2 was used to produce fast dissolving tablets, except that the generic tablet in Example 2 above was contacted with supercritical fluid at a temperature of 40° C. and a pressure of 80 bar for 90 minutes. The extraction rate of the supercritical fluid-soluble matter is 101.0%.

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Abstract

The present invention provides a fast dissolving oral tablet, and a method for the production thereof, comprising the steps of: compressing a mixture of active ingredients, pharmaceutically allowable additives, and supercritical fluid-soluble substances to produce the tablets; and allowing the tablets to contact a supercritical fluid to extract supercritical fluid-soluble substances and form fine pores in the tablets.

Description

technical field [0001] The present invention relates to fast dissolving oral tablets and methods for their preparation, and more particularly, to porous rapidly dissolving oral tablets prepared by a supercritical fluid extraction process and methods for their preparation. Background technique [0002] Usually, tablets or capsules should be taken with 200-250 mL of water, but these methods of administration may be uncomfortable or impossible for some patients. In particular, for the elderly, infants, children, people who have difficulty swallowing, patients who need to limit their water intake, and patients who are difficult to take care of themselves due to physical and mental reasons, such as dementia, Parkinson's disease, etc. The method is difficult to apply to these populations. In this case, preferably, a rapidly dissolving tablet (hereinafter, referred to as "quickly dissolving tablet") that is easily dissolved by saliva in the mouth or easily transformed in a liquid ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/22A61K9/20A61K47/02A61K47/26A61K47/38
CPCA61K9/0056A61P25/04A61K9/20
Inventor 李恃氾赵日焕李高银安泰军洪一基郑善五李镕宅申京珉尹明植
Owner CJ CHEILJEDANG CORP
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