Deer ossein polypeptide chelated calcium and enteric capsule and preparation method of enteric capsule

A technology of polypeptide chelating calcium and collagen polypeptide, which is applied in the preparation methods of peptides, chemical instruments and methods, capsule delivery, etc., can solve the problems of low oral bioavailability, etc., to increase oral bioavailability and enhance bioavailability , the effect of increasing calcium absorption

Inactive Publication Date: 2011-11-16
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented technology provides an improved method for making small molecules that can help make pills easier to swallow through stomachs without causing damage during digestion. These tiny particles have been found effective at stimulating cellular activity when taken up by cells called phagocytes (immune system). They also improve their ability to absorb calcium while being ingested with food containing certain nutrients like iron supplements.

Problems solved by technology

This patented technology describes how deerbone plays important roles during growth and development processes like regulating mineral homeostasis and reducing risk factors associated with degenerative joint disease. Its technical effects include improved health outcomes related to reduced inflammations, improvement of bone quality, reduction of pain without side effects, and stimulate cellular responses involved in maintaining strong bone tissue.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] First weigh 10kg of crushed deer bone, after degreasing, decalcifying and removing impurities, add 500u / g pepsin; adjust the pH to 1.7, incubate at 37°C for 8h, add 70000mL of water, ultrasonically extract for 2h, and concentrate to 3500mL , spray-dried; add 3000u / g papain, adjust the pH to 5.7, hydrolyze at 55°C for 2h, add 10000mL of water, ultrasonically extract for 1.5h, concentrate to 500mL, and spray-dry. Add 8000mL of deionized water, add 160g of calcium hydroxide, mix well, adjust the pH to 7.0, react at 55°C for 3h, add 4 times the volume of 95% ethanol, centrifuge at 5000rpm for 10min, collect the supernatant, and concentrate it to 800ml, freeze-dried; identified as deer bone collagen polypeptide chelated calcium by ninhydrin-sodium sulfate method.

Embodiment 2

[0030] Weigh 10kg of crushed deer bone, degrease, decalcify and remove impurity protein, add 600u / g Pellvit C alkaline protease, adjust the pH to 9, incubate at 40°C for 8h, add 100000mL of water, ultrasonically extract for 2h, concentrate To 3500mL, spray dry. Add 3000u / g pepsin, adjust the pH to 1.7, hydrolyze at 37°C for 2h, add 10000mL of water, ultrasonically extract for 1.5h, concentrate to 500mL, and spray dry. Add 8000mL of deionized water, add 160g of deer bone calcium, mix well, adjust the pH to 7.0, react at 55°C for 1.5h, add 4 times the volume of 95% ethanol, centrifuge at 5000rpm for 10min, collect the supernatant, and concentrate it to 800ml, freeze-dried; identified as deer bone collagen polypeptide chelated calcium by ninhydrin-sodium sulfate method.

Embodiment 3

[0032] Weigh 10kg of crushed deer bone, degrease, decalcify and remove impurities, add 600u / g trypsin, adjust the pH to 8, incubate at 37°C for 8h, add 80000mL of water, ultrasonically extract for 2h, concentrate to 3500mL, Spray dry. Add 3500u / gl of Pellvit C alkaline protease, adjust the pH to 9, incubate at 40°C, hydrolyze for 2h, add 10000mL of water, ultrasonically extract for 1.5h, concentrate to 500mL, and spray dry. Add 8000mL of deionized water, add 200g of calcium chloride, mix well, adjust the pH to 7.0, react at 50°C for 2h, add 4 times the volume of 95% ethanol, centrifuge at 5000rpm for 10min, collect the supernatant, and concentrate it to 800ml, freeze-dried; identified as deer bone collagen polypeptide chelated calcium by ninhydrin-sodium sulfate method.

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Abstract

The invention provides a deer ossein polypeptide chelated calcium enteric capsule and a preparation method thereof. The deer ossein polypeptide chelated calcium enteric capsule is a novel polypeptide chelated calcium preparation, and osteoporosis caused by age increasing, menostasia and the like can be prevented and treated from two aspects, namely increasing calcium absorption and promoting collagen metabolism. Under the protection action of polypeptide chelated calcium deer ossein polypeptide, bioavailability of the bioactive peptide is enhanced, and multiple physiological functions such as immunity enhancement and the like of the bioactive peptide are played; and the deer ossein polypeptide chelated calcium is prepared into the enteric capsule, thus the polypeptide chelated calcium in the enteric capsule is protected from being damaged by gastric acid environment and oral bioavailability is enhanced.

Description

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Claims

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Application Information

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Owner JILIN UNIV
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