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System for promoting bystander effect of radiotherapy by utilizing low-intensity ultrasound

A radiotherapy, low-intensity technology, applied in the field of systems where low-intensity ultrasound stimulation promotes the side effects of tumor radiotherapy, and can solve problems such as affecting the dose efficiency of radiotherapy

Inactive Publication Date: 2011-11-23
TIANJIN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The bystander effect can compensate to a certain extent the influence of non-uniform dose distribution on the effect of radiotherapy, and the activation of bystander effect factors can affect the dose efficiency of radiotherapy[2]

Method used

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  • System for promoting bystander effect of radiotherapy by utilizing low-intensity ultrasound
  • System for promoting bystander effect of radiotherapy by utilizing low-intensity ultrasound
  • System for promoting bystander effect of radiotherapy by utilizing low-intensity ultrasound

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Embodiment Construction

[0030] The system for using low-intensity ultrasound to promote radiotherapy side effects of the present invention will be described in detail below in conjunction with the accompanying drawings and embodiments.

[0031] Such as figure 1As shown, the system of the present invention that uses low-intensity ultrasound to promote radiation therapy side effects includes a radiation source and an ultrasound source. The tumor target area 1 is irradiated with radioactive sources for radiotherapy. The radiation source may be an external radiation beam 2 or an internal radiation source placed in the tumor target volume 1, such as in the case of brachytherapy. The low-intensity stimulating ultrasonic probe 4 is used to provide low-intensity ultrasonic stimulation to the tumor target area 1 . The ultrasound probe can be an external ultrasound probe as shown in the figure, or an intracavity ultrasound probe. Ultrasound imaging system is used to locate the tumor target area. In this em...

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Abstract

The invention belongs to the field of the radiotherapy of tumors, and relates to a system for promoting a bystander effect of radiotherapy by utilizing low-intensity ultrasound. The system comprises an imaging unit for performing image positioning on a tumor target region, a radioactive source for providing the radiotherapy for the tumor target region and an ultrasound source for performing ultrasound irritation on the tumor target region, so that the tumor target region is subjected to low-intensity ultrasound irritation while being subjected to the radiotherapy, wherein the intensity range of the ultrasound source is between 10 and 3,000mW / cm<2> preferably, and the frequency range is between 20 KHz and 1MHz preferably. By the system, the bystander effect of the radiotherapy of the tumors can be promoted, and the effect of the radiotherapy can be improved.

Description

technical field [0001] The patent of the present invention belongs to the field of tumor radiotherapy, and in particular relates to a system that uses low-intensity ultrasonic stimulation to promote the side effect of tumor radiotherapy. Background technique [0002] Radiation therapy, as one of the main treatment methods, plays an important role in the clinical treatment of tumors. On average, about 70% of malignant tumor patients need to receive radiation therapy. Therefore, effectively improving the effect of radiation therapy is of great significance for improving the cure rate or improving the quality of life of patients, and it is an urgent problem in the field of tumor radiation therapy. [0003] Radiation-induced bystander effects mean that tissue cells that are not directly irradiated by radiation exhibit similar biological effects to tissue cells that are directly irradiated, such as: apoptosis, gene mutation, gene expression changes, micronuclei, gene instability...

Claims

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Application Information

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IPC IPC(8): A61N5/10A61N7/00
Inventor 冯远明杨春梅
Owner TIANJIN UNIV
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