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Sequential and repeated application of four or more HIV vector gene vaccines

A carrier vaccine and vaccine technology, applied in the field of biomedicine, can solve the problem of restricting the repeated application of vaccines, and achieve the effect of long-term maintenance of high level, good specific immune response, and prolonged time

Active Publication Date: 2011-11-30
中国疾病预防控制中心病毒病预防控制所
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Carrier vaccines can induce a good cellular immune response, but the immunogenicity of the carrier itself greatly limits the repeated application of the vaccine, so it is necessary to sequentially apply a variety of carrier vaccines that can well induce HIV-specific immune responses to achieve The effect of being able to treat multiple times in the patient's body

Method used

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  • Sequential and repeated application of four or more HIV vector gene vaccines
  • Sequential and repeated application of four or more HIV vector gene vaccines
  • Sequential and repeated application of four or more HIV vector gene vaccines

Examples

Experimental program
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Effect test

Embodiment Construction

[0019] HIV vaccine sequential and repeated immunization experiment in rhesus monkeys

[0020] 1. Vaccination and grouping

[0021] Eight adult rhesus monkeys were randomly divided into 3 groups. Group 1 and 2 were PBS control groups. At all the same immunization time points as the experimental group, 1ml sterile PBS was injected intramuscularly; Group 2 5 were four vaccine-immunized groups , First use DNA in 0 weeks and immunize twice in 2 weeks (The DNA vaccine used is a eukaryotic expression plasmid expressing the codon-optimized gag gene, which is a prior patent application filed by the applicant in 2006 with the application number 200610098946.1 The constructed pVR-mod.gag, produced by Benyuan Zhengyang Gene Technology Co., Ltd.), was immunized with the same dose of adenovirus vaccine rAd5-gag (rAd5-gag is E1, which expresses mod.gag gene) at 6 and 33 weeks. The replication-defective recombinant type 5 adenovirus with E3 deletion, the expressed promoter is mCMV, and the tailin...

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Abstract

The invention relates to a sequential and repeated application strategy of four or more HIV (human immunodeficiency virus) vector gene vaccines, capable of maintaining high-level specific immune response for a long time. The combined AIDS (acquired immune deficiency syndrome) vaccine for preventing and / or treating AIDS is capable of activating broad-spectrum anti-AIDS virus cellular immune response, and is composed of four or more AIDS vaccines. The different AIDS vaccines can contain the same HIV protein gene, one kind of AIDS vaccine is inoculated once, and each kind of vaccine can be inoculated twice continuously. After the four or more kinds of different vector vaccines are sequentially applied, the vector vaccines can be repeatedly and sequentially applied.

Description

Technical field [0001] The invention belongs to the field of biomedicine. The invention relates to an immunization strategy for sequential and repeated application of four or more HIV carrier gene vaccines. The specific application will not be limited to the four vaccines used in this preliminary study. Background technique [0002] Human immunodeficiency virus (HIV) belongs to the human lentivirus group in the genus Lentivirus of the retroviral family. It is the pathogen of acquired immunodeficiency syndrome (AIDS), which was first recognized in 1983. Identification. AIDS is considered to be the world's largest infectious disease that directly threatens human health, and has become an important public health problem worldwide. The 2009 Global AIDS Epidemic Trend Report jointly issued by the UNAIDS and the World Health Organization shows that there are currently approximately 33.4 million people living with AIDS in the world, of which 2.7 million were newly infected in 2008 an...

Claims

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Application Information

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IPC IPC(8): A61K39/21A61K48/00A61P31/18
CPCA61K2039/523A61K2039/5256A61K39/21A61K48/00A61K39/12A61K2039/53C12N2740/16034A61K2039/5258A61K2039/545A61P31/18C12N2710/10343C12N2710/24143C12N2740/16234C12N2760/18843
Inventor 曾毅冯霞余双庆杨玲李泽林孔维于湘晖
Owner 中国疾病预防控制中心病毒病预防控制所
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