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Drugs used to treat nephritis

A technology of medicine and nephritis, applied in the field of medicine for treating nephritis, can solve the problems of complex composition of active ingredients and complicated preparation methods, and achieve significant diuretic effect, shorten extraction time, and high purity

Inactive Publication Date: 2011-12-14
吉林省生物研究所 +3
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the preparation method of this traditional Chinese medicine is relatively complicated, and the active ingredients of each component need to be extracted separately, and the composition of the extracted active ingredients is relatively complicated.

Method used

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  • Drugs used to treat nephritis
  • Drugs used to treat nephritis
  • Drugs used to treat nephritis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] The preparation of embodiment 1 ramie extract

[0070] Cut the peduncle stems from Changbai Mountain into pieces of 0.5cm to 4cm, soak 1kg of peduncle in 5kg of petroleum ether for 4 hours, reflux and extract for 1 hour, pour off the petroleum ether, and volatilize the petroleum ether in the obtained medicine dregs Clean; add 5 kg of ethanol with a mass concentration of 90% to the obtained medicinal residues, and reflux for 2 hours to obtain the first extract of Fructus Echinacea and residual medicinal residues; add 5 kg of ethanol with a mass concentration of 90% to the residual medicinal residues, and continue to reflux extracting for 1.5 hours to obtain the second extract of ramie extract; combining the first extract and the second extract and recovering the ethanol therein until the concentration of total flavonoids in the obtained extract reaches 6 mg / mL; Use hydrochloric acid to adjust the pH value of the extract of Prunus edulis to 4.5, and then filter it with ab...

Embodiment 2

[0072] Embodiment 2 animal acute toxicity test

[0073] Test drug: the medicinal suspension prepared by dissolving the extract of Fructus Radix Puerariae prepared in Example 1 in water;

[0074] Experimental animals: healthy female Kunming mice provided by the Animal Experiment Center of Jilin University School of Basic Medicine, weighing 19g-22g;

[0075] 2.1 One-time gavage administration of LD 50 determination

[0076] Take 20 female healthy mice, and after fasting for 16 hours, give 1mL / one of the drug suspension with a mass concentration of 47.5% orally, and observe the state of the mice after administration. The results show that the activity status of the mice is normal, and the vital signs Normal, no one died after 7 days of observation, so it is necessary to measure the maximum dosage;

[0077] 2.2 Determination of the maximum dosage of intragastric administration

[0078] Take 30 healthy female mice, and give them a drug suspension with a mass concentration of 47...

Embodiment 3

[0082] The influence of embodiment 3 medicines on chronic glomerulonephritis

[0083] Medicine: the medicinal suspension prepared by dissolving the extract of Fructus Radix Puerariae prepared in Example 1 in water;

[0084] Animals: Wistar rats purchased from the Animal Experiment Center of Bethune Medical College of Jilin University, male and female, 180g-210g;

[0085] Reagent: Freund's complete adjuvant produced by Beijing Dingguo Biotechnology Co., Ltd.;

[0086] Instrument: GF-D800 biochemical analyzer produced by Shandong Gaomi Rainbow Analytical Instrument Co., Ltd.; YDA-IV blood viscometer produced by Beijing Hongrunda Technology Development Co., Ltd.;

[0087] Data processing: Statistical methods Data are expressed as x±s, and t test is used for comparison between groups.

[0088] 3.1 The impact on chronic glomerulonephritis

[0089] 3.1.1 Preparation of Renal Cortex Freund's Complete Adjuvant Suspension

[0090] Take 20-month-old healthy Wistar rats, kill them by...

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Abstract

The medicine for the treatment of nephritis provided by the present invention includes the extract of the branch of the branch, and the extract of the branch of the branch is prepared according to the following method: firstly, the branch of the branch of the branch is soaked in petroleum ether, and the dregs are obtained after reflux extraction; After the slag is refluxed and extracted in ethanol, the extract of the seeds of the sage is obtained; the extract of the seeds of the sage is purified by using a macroporous adsorption resin to obtain the extract of the sage. Experiments show that the medicine provided by the invention has a therapeutic effect on rats with chronic nephritis; the medicine provided by the invention has a significant diuretic effect; during the occurrence and development of chronic nephritis, the blood coagulation mechanism disorder generally exists in the body and is in a hypercoagulable state. And it is an important factor for the continuous development of lesions and the progressive decline of renal function. The medicine provided by the invention can significantly reduce high shear, low shear and plasma specific viscosity, indicating that it has a significant effect on improving the hypercoagulation state.

Description

technical field [0001] The invention belongs to the technical field of medicines, in particular to a medicine for treating nephritis. Background technique [0002] Nephritis is a non-suppurative inflammatory lesion of the kidneys on both sides. It is the phenomenon of edema, high blood pressure, and proteinuria caused by damage to the renal corpuscles. It is the most common type of kidney disease. Nephritis is an immune disease, which is an inflammatory reaction mediated by renal immunity. After different antigenic microorganisms infect the human body, different antibodies are produced, combined into different immune complexes, and deposited in different parts of the kidney to cause pathological damage. [0003] Nephritis is difficult to cure due to its complex etiology. Western medicine generally treats clinical symptoms such as proteinuria and hematuria under the conditions of hospital bed rest, salt restriction, and protein restriction. It treats the symptoms but not the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/48A61P13/12
Inventor 张金亭向鲁湘宋文慧王强张松玲刘伟赵丽茹黄勇于文斌李金花秦玲
Owner 吉林省生物研究所
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