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Use of angelica extract as a medicament for preventing skin aging

A technology of skin aging and extracts, applied in skin care preparations, skin diseases, applications, etc., can solve the problems of pathological conditions, pathological conditions deterioration, tissue function and/or structure loss, etc.

Inactive Publication Date: 2011-12-14
TAIWAN SUGAR CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when MMPs are overactivated, pathological conditions can be caused or aggravated, resulting in loss of tissue function and / or structure

Method used

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  • Use of angelica extract as a medicament for preventing skin aging
  • Use of angelica extract as a medicament for preventing skin aging
  • Use of angelica extract as a medicament for preventing skin aging

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0031] Example 1 Preparation of Taiwan angelica extract sample

[0032] This example uses tianxian fruit produced in Taiwan as the raw material, and the Taiwanese tianxian fruit used has passed the "Taiwan tianxian fruit pesticide and heavy metal limit standard value".

[0033] Get Taiwan's angelica (dry material purchase), get its appearance as part of the roots, part of the inclusions are less than four centimeters of flakes, grind to pass through a 30-hole sieve. Test the moisture content according to the operating instructions of the infrared moisture analyzer, and control the moisture content of the Taiwan angelica sample to less than 10%.

[0034] Take 50 grams of the above-mentioned tianxian fruit with a moisture content of less than 10% and place it in a 1-liter four-neck flat-bottomed flask, add 500 ml of 100% methanol, heat and reflux for extraction for 4 hours, centrifuge and filter, quantify the volume of the filtrate (V1) and take 1 mL of filtrate for subsequent ...

example 2

[0036] The preparation of example 2 standard substance and blank solution

[0037] Weigh 5 mg of apigenin and place it in a 2 mL volumetric flask, add a little methanol and shake to dissolve, then add methanol to the mark to make the standard concentration 2500 μg / mL. Then according to the volume indicated in Table 2, methanol was added to serially dilute the standards with different concentrations:

[0038] Table 2 Apigenin standard concentration

[0039] Concentration (μg / mL); ppm 0 100 200 300 400 500

[0040] 2500μg / mL Standard (mL) 0 0.08 0.16 0.24 0.32 0.4

[0041] Methanol (mL) 2 1.92 1.84 1.76 1.68 1.6

[0042] Above-mentioned different concentration standard substance solutions, after HPLC analysis, take the concentration of standard substance as the abscissa value, and the peak area value is the ordinate value and do linear regression analysis, obtain the X-Y straight line passing through the origin, when standard curve correlation coefficient (R2) 0.999 ~1, can ...

example 3

[0043] Example 3 Angelica extract of the present invention and standard HPLC analysis test

[0044] HPLC analysis equipment and method

[0045] Material

[0046] All solvents and reagents were HPLC grade (purchased from Merck). Apigenin (purchased from Sigma).

[0047] instrument

[0048] American Waters (WATERS) high performance liquid chromatography system (LC module type I (LC-Module I)). Analytical balance, readable to 0.1 mg.

[0049] HPLC analysis conditions

[0050] The chromatographic column is ODS3, C18 column (250×4.6mm, 5μm) (purchased from Varian (Varian)), the column temperature is room temperature, the measurement wavelength is 254nm, the injection volume is 15μL, the mobile phase speed is 0.8mL / min, and methanol As a sample solvent, the analysis time was 42 minutes. Before injection, each sample was filtered through a 0.45 μm nylon (Nylon) filter membrane. After sample injection, the C18 column is filtered with a guard column.

[0051] Mobile phase prep...

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PUM

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Abstract

The invention provides a composition for preventing skin aging. The composition contains ficus formosana maxim extract. The invention also provides a cosmetic which contains ficus formosana maxim extract and can prevent skin aging. The invention also relates to application of ficus formosana maxim extract in preparation of the composition for preventing skin aging.

Description

technical field [0001] The present invention relates to jasmine extract and its use for preventing skin aging. Background technique [0002] Tianxian fruit is a plant of the genus Ficus genus in the Moraceae family. It is also known as Taiwan banyan, Xiaoben Niu Rupu, Yang Niutou, Yang milk boy, Shanjinzao, Shanbazi, Yudaijiao, etc. Tianxian fruit is distributed in the broad-leaved forests or wild bushes from the foothills to low-altitude mountainous areas in mainland China, Hong Kong, Vietnam, and Taiwan. It can also be found in low-altitude mountainous areas in eastern Taiwan. Tianxian fruit plant is an evergreen shrub, the whole plant contains white latex, the leaves are alternate with short stalks, the shape of the leaves is oblong, lanceolate or rhomboid, entire or with sparse serrations, and the shape of the leaves varies greatly , the leaf color is silver or green, the fruit is ovate or obovate, the fruit is green when immature, with white spots on the surface, and t...

Claims

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Application Information

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IPC IPC(8): A61K36/60A61K8/97A23L1/29A61Q19/08A61P17/02A61P17/16A61K125/00A61K131/00A23L33/00
Inventor 杨寄明黄怡仁吕思洁陈嘉琪
Owner TAIWAN SUGAR CORP
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