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A kind of western medicine compound and application for treating coronary heart disease

A technology for coronary heart disease and compound prescription, applied in the field of western medicine, can solve the problems of no literature report on the combined application of aliskiren and statins, no literature report on the combination of aliskiren/statin and western medicine, etc.

Inactive Publication Date: 2011-12-21
THE FIRST AFFILIATED HOSPITAL OF XINXIANG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there are no literature reports on the combined application of aliskiren and statins, and no literature reports on the combination of aliskiren / statins

Method used

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  • A kind of western medicine compound and application for treating coronary heart disease
  • A kind of western medicine compound and application for treating coronary heart disease
  • A kind of western medicine compound and application for treating coronary heart disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Preparation of Example 1 Rosuvastatin Calcium / Aliskiren Compound Tablet

[0027] Prescription content:

[0028]

[0029] Preparation process: Aliskiren, rosuvastatin calcium, starch, lactose, and low-substituted hydroxypropyl cellulose were weighed and mixed uniformly. Another appropriate amount of 60% ethanol is added to the mixed powder, mixed evenly, made into soft material, passed through a 18-mesh sieve to make wet granules, dried at about 60°C, granulated with a 20-mesh sieve, added magnesium stearate, mixed evenly, and pressed into tablets , that is.

Embodiment 2

[0030] The preparation of embodiment 2 simvastatin / aliskiren compound tablet

[0031] Prescription content:

[0032]

[0033] Preparation process: Aliskiren, simvastatin, pregelatinized starch, microcrystalline cellulose, and croscarmellose sodium were weighed and mixed uniformly. Another appropriate amount of 60% ethanol is added to the mixed powder, mixed evenly, made into soft material, passed through a 18-mesh sieve to make wet granules, dried at about 60°C, granulated with a 20-mesh sieve, added magnesium stearate, mixed evenly, and pressed into tablets , that is.

Embodiment 3

[0034] Example 3 Effect of Simvastatin / Aliskiren Compound on Myocardial Infarction Model Rats

[0035] Male SD rats weighing 230-260 g were selected, and 10 rats were set aside as the normal group, and the remaining rats were anesthetized by intraperitoneal injection of 30 mg / kg pentobarbital. Fix the back position, use more than half of the suction ball (the size is just set on the rat's head), use the ALC-V8 animal ventilator, the tidal volume is 10ml / kg, the respiratory rate is 45-50 times / min, and the respiratory ratio is 1:1 . Hair removal on the chest, disinfection, longitudinal skin incision 20 mm along the left midline of the clavicle, blunt separation of the muscle layer between the 4th and 5th intercostals, use curved hemostatic forceps to stretch the intercostal muscles and pleura into the thoracic cavity, cut the pericardium, lightly use the middle finger Press the right thoracic corridor, press the lower part of the xiphoid process with the thumb, squeeze out the...

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PUM

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Abstract

The invention relates to a western medicine compound for curing coronary diseases and medical application thereof. The active ingredients of the western medicine compound comprise the following two medicines: (1) aliskiren or pharmaceutically acceptable salts thereof; and (2) statins, wherein the statins include simvastatin or rosuvastatin calcium. The compound medicine disclosed by the invention has obvious curable effects on myocardial ischemia type coronary diseases, myocardial infarction type diseases and angina type coronary diseases.

Description

technical field [0001] The invention relates to a pharmaceutical composition and its application, in particular to a western medicine compound for treating coronary heart disease and its medical application, belonging to the technical field of western medicine. Background technique [0002] Coronary heart disease is the main killer of human health. With the acceleration of globalization, cardiovascular and cerebrovascular diseases have begun to spread in developing countries and become the number one cause of death in the world. The World Health Organization classifies coronary heart disease as follows: (1) Asymptomatic myocardial ischemia: also known as painless myocardial ischemia or occult myocardial ischemia, it refers to the objective evidence of myocardial ischemia (cardiac electrical activity, left Abnormalities of ventricular function, myocardial perfusion and myocardial metabolism), but lack of chest pain or subjective symptoms related to myocardial ischemia. (2) A...

Claims

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Application Information

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IPC IPC(8): A61K31/366A61K31/165A61K31/505A61P9/10
Inventor 不公告发明人
Owner THE FIRST AFFILIATED HOSPITAL OF XINXIANG MEDICAL UNIV
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