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Method for preparing taxillus chinensis danser extract and application

A technology of duck foot veneer and extract, which is applied in the field of research and development of pharmaceutical products, can solve the problems that the research on the anti-inflammatory and analgesic effects of duck foot veneer extract has not been reported yet, achieve significant anti-inflammatory and analgesic activity, and the preparation method is simple and Appropriate effect for promoting the application

Inactive Publication Date: 2013-09-18
GUANGDONG PHARMA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report on the anti-inflammatory and analgesic effects of duck foot veneer extract

Method used

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  • Method for preparing taxillus chinensis danser extract and application
  • Method for preparing taxillus chinensis danser extract and application
  • Method for preparing taxillus chinensis danser extract and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The preparation of embodiment 1 duck foot veneer extract

[0023] (1) Get the bark powder of Schefflera octophylla (Lour.) Harms (the particle size of the powder is not strictly limited), and use 10 times the volume ratio concentration of 95% ethanol to reflux extract 3 times, each time for 2 hours , static filtration;

[0024] (2) Merge step (1) gained filtrate, reclaim solvent under reduced pressure and obtain total extract;

[0025] (3) Suspend the total extract obtained in step (2) with an appropriate amount of water (the amount of water is about 3 to 5 times the mass of the total extract), and then sequentially extract each extract with petroleum ether, chloroform, ethyl acetate and n-butanol. 3 times, the amount of extractant is 1 to 2 times that of the aqueous solution;

[0026] (4) merging step (3) gained sherwood oil layer, chloroform layer, ethyl acetate layer and n-butanol layer extract respectively;

[0027] (5) The obtained petroleum ether layer, chlorof...

Embodiment 2

[0028] The preparation of embodiment 2 duck foot veneer extract

[0029] (1) Take the bark powder of Schefflera octophylla (Lour.) Harms), extract it twice with 85% ethanol at a concentration of 8 times the volume ratio, and extract it twice for 2.5 hours each time, and let it stand and filter;

[0030] (2) Merge step (1) gained filtrate, reclaim solvent under reduced pressure and obtain total extract;

[0031] (3) Suspend the total extract obtained in step (2) with water (the amount of water is about 3 to 5 times the mass of the total extract), and then sequentially extract each 4 times with petroleum ether, chloroform, ethyl acetate and n-butanol ; (extractant consumption is 1~2 times of aqueous solution)

[0032] (4) merging step (3) gained sherwood oil layer, chloroform layer, ethyl acetate layer and n-butanol layer extract respectively;

[0033] (5) The obtained petroleum ether layer, chloroform layer, ethyl acetate layer and n-butanol layer extract and the water layer ...

Embodiment 3

[0034] The preparation of embodiment 3 duck foot veneer extract

[0035] (1) Take the bark powder of Schefflera octophylla (Lour.) Harms, extract it with 9 times volume ratio concentration of 75% ethanol under reflux for 3 times, each time for 2 hours, let stand and filter;

[0036] (2) Merge step (1) gained filtrate, reclaim solvent under reduced pressure and obtain total extract;

[0037] (3) Suspend the total extract obtained in step (2) with water (the amount of water is about 3 to 5 times the mass of the total extract), and then sequentially extract each 4 times with petroleum ether, chloroform, ethyl acetate and n-butanol ; (extractant consumption is 1~2 times of aqueous solution)

[0038] (4) merging step (3) gained sherwood oil layer, chloroform layer, ethyl acetate layer and n-butanol layer extract respectively;

[0039] (5) The obtained petroleum ether layer, chloroform layer, ethyl acetate layer and n-butanol layer extract and the water layer after the extraction ...

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Abstract

The invention discloses a method for preparing a taxillus chinensis danser extract, an extract and application. The method comprises the following steps of: taking an ethanol extract of taxillus chinensis danser powder; sequentially extracting by using petroleum ether, chloroform, ethyl acetate and n-butyl alcohol; respectively mixing various extract liquor and aqueous solution; and decompressingand recovering solvent to obtain a petroleum ether extract, a chloroform extract, an ethyl acetate extract and an n-butyl alcohol extract. The taxillus chinensis danser extract disclosed by the invention has good anti-inflammatory analgesic activity and can be applied to preparing anti-inflammatory analgesic drugs.

Description

technical field [0001] The invention belongs to the technical field of research and development of pharmaceutical products, and relates to a preparation method and application of duck foot veneer extract. Background technique [0002] Schefflera octophylla (Lour.) Harms is a plant of the genus Schefflera octophylla of Araliaceae, which has a bitter taste and flat nature. The root bark and bark of this plant can be used as medicine. It has the functions of expelling wind and dampness, promoting blood circulation and relieving pain. Wait. Duckfoot wood is mainly distributed in Yunnan, Guangdong, Guangxi and other places. It is rich in resources and is a nectar source plant in the south in winter. It has high medicinal value and has great potential for development. [0003] Inflammation is a defensive reaction of living tissue with vascular system to injury factors, and it is involved in the pathogenesis of many diseases. It is a common and frequently-occurring disease, and i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/25A61P29/00A61P19/02A61P19/08A61P11/04A61K129/00
Inventor 沈志滨陶曙红曾凡林陈艳芬尹永芹崔红花
Owner GUANGDONG PHARMA UNIV
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