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Application of Cathelicidin-bf Antimicrobial Peptide from Golden Krait

A technology of antibacterial peptide and action of golden ring snake, which can be applied in the field of biomedicine and can solve the problem that the active ingredients of drugs cannot function better.

Inactive Publication Date: 2011-12-28
KUNMING INST OF ZOOLOGY CHINESE ACAD OF SCI
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0006] At the same time, the complexity of the ingredients of traditional Chinese medicine and the limitations of its processing methods prevent the active ingredients of the medicine from playing a better role. Therefore, it is one of the important contents of the modernization of traditional Chinese medicine to find specific active monomer compounds from these traditional medicines.

Method used

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  • Application of Cathelicidin-bf Antimicrobial Peptide from Golden Krait
  • Application of Cathelicidin-bf Antimicrobial Peptide from Golden Krait
  • Application of Cathelicidin-bf Antimicrobial Peptide from Golden Krait

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Embodiment Construction

[0026] The following examples are used to further illustrate the essential content of the present invention, but the content of the present invention is not limited thereto.

[0027] 1. To investigate the sensitivity of two common bacterial vaginosis pathogens (Staphylococcus aureus and Escherichia coli) to cathelicidin-BF

[0028] 1. Material

[0029] 1.1 Strains: Staphylococcus aureus (11 strains) and Escherichia coli (10 strains) isolated from patients with bacterial vaginosis infection.

[0030] 1.2 Medium nutrient agar, broth, Mueller-Hinton (MH) agar medium (bacteria), sand castle agar medium.

[0031] 1.3 Drugs: chemical synthesis of cathelicidin-BF, bacitracin, ciprofloxacin, ampicillin and azithromycin.

[0032] 2 Investigate the sensitivity of drug-resistant bacteria to cathelicidin-BF

[0033] 2.1 The agar plate dilution method was used to determine the MIC of cathelicidin-BF to Staphylococcus aureus and E. coli. Take 12 sterile test tubes (10ml) and arrange them in a row. Ad...

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Abstract

The invention belongs to the technical field of biomedicine, and in particular relates to the application of cathelicidin-BF, an antibacterial peptide of ceratopsia, in the preparation of medicines for treating bacterial vaginosis. The antibacterial peptide cathelicidin-BF of the present invention has the beneficial characteristics of strong bactericidal effect and rapid sterilization on Staphylococcus aureus and Escherichia coli in vitro; the effect of cathelicidin-BF on vaginitis caused by E. The results of coccus-infected vaginitis are basically the same, and it can significantly inhibit Staphylococcus aureus or Escherichia coli in the vagina, and cathelicidin-BF has an obvious effect of reducing inflammation; it can be used in the preparation of drugs for treating bacterial vaginosis.

Description

Technical field: [0001] The invention belongs to the technical field of biomedicine, and specifically relates to the application of the golden snake antibacterial peptide cathelicidin-BF in the preparation of a medicine for treating bacterial vaginitis. Background technique: [0002] Cathelicidin is a family of multifunctional antimicrobial peptides, currently only found in mammals, birds and fish. Cathelicidin has a broad-spectrum antibacterial activity. It not only has very strong bactericidal activity against Gram-positive bacteria, Gram-negative bacteria, certain fungi and viruses, but also has an effect on many clinically resistant bacteria. In addition, cathelicidin also has many other biological activities, such as chemotaxis on a variety of immune cells, inducing mast cell degranulation and histamine release, regulating macrophage transcription, promoting wound healing, inducing angiogenesis, inducing mutation Cell line apoptosis and lymphocyte activation. With so many ...

Claims

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Application Information

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IPC IPC(8): A61K38/17A61P31/04A61P15/02
Inventor 赖仞张治业李东升刘蕊
Owner KUNMING INST OF ZOOLOGY CHINESE ACAD OF SCI
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