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Agent for preventing, inhibiting, or ameliorating skin aging due to buildup of advanced glycation end products

A technology of advanced glycosylation and end products, which is applied in the field of skin aging prevention, inhibition or improvement agent, which can solve the problems of hindering pentosidine, so as to improve skin firmness, improve skin dark yellow, and inhibit skin aging Effect

Inactive Publication Date: 2012-02-15
ROHTO PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, in Patent Document 1, it is described that citrus volatile oils inhibit the production of pentosidine, which is one of AGEs

Method used

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  • Agent for preventing, inhibiting, or ameliorating skin aging due to buildup of advanced glycation end products
  • Agent for preventing, inhibiting, or ameliorating skin aging due to buildup of advanced glycation end products
  • Agent for preventing, inhibiting, or ameliorating skin aging due to buildup of advanced glycation end products

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-1

[0304] Embodiment 1-1 (measurement of AGEs degradation performance)

[0305] (1) Test sample (vegetable oil and fatty acid)

[0306] Evening primrose oil was purchased from ORYZA Oil & Chemical Co., Ltd. and Nissin Oiliyo Group Co., Ltd. Brazilian nectarine oil was purchased from Croda Japan Co., Ltd. γ-linolenic acid, α-linolenic acid, available from Cayman Chemical Co. Linoleic acid and oleic acid were purchased from Wako Pure Chemical Industries, Ltd. Docosahexaenoic acid (DHA), available from ChromaDex, Inc. Evening primrose extract was purchased from ORYZA Oil Chemical Co., Ltd.

[0307] (2) Measurement method

[0308] It is known that AGEs are decomposed by cleaving the interketone C-C bond of the α-diketone structure present in AGEs. With reference to the method described in Japanese Patent Application Laid-Open No. 2007-161662, by measuring the cleavable performance of the C-C bond between ketones of 1-phenyl-1,2-propanedione (hereinafter referred to as PPD...

Embodiment 1-2

[0325] Embodiment 1-2 (study on the influence that skin color produces)

[0326] Evening primrose oil is evening primrose oil purchased from The Nisshin OilliO Group, Ltd. (The Nisshin OilliO Group, Ltd.).

[0327] Four forearm regions of adults in their 20s to 40s (group of four) were divided into 2 cm x 2 cm areas as test sites. Evening primrose oil was applied to 4 test sites at 0.05 ml / area twice a day (morning and evening). The forearm site of each test subject to which no application was applied was used as a control. Before the start of application and after 28 days of application, the skin color (b * value). b * The value is an indicator of chromaticity, with higher values ​​indicating stronger yellow and lower values ​​indicating stronger cyan.

[0328] The b obtained by applying the test sample during 28 days * value variation, shown in Tables 1-3 below and Picture 1-1 middle. Tables 1-3 and Picture 1-1 The values ​​in are the measured values ​​of 4 parts ...

Embodiment 1-3

[0332] Embodiment 1-3 (study on the influence that skin elasticity produces)

[0333] In the same manner as in Example 1-1, the test sample was applied to the forearm of the subject. After 28 days of application, a skin elasticity measuring instrument (manufactured by Integral Corporation, Cutometer SEM575) was used to suck the application part of the skin with 300 mbar pressure for 2 seconds and then release it for 2 seconds to measure the height change of the skin, thereby evaluating the elasticity of the skin.

[0334] The ratio (Ua / Uf) of the height recovery portion (Ua) caused by release to the skin height (Uf) at the time of maximum suction was used as an index showing skin elasticity. In addition, the ratio (Ur / Ue) of the recovery portion (Ur) of the height after release for 0.1 second to the skin height (Ue) after suction for 0.1 second was used as an index indicating the degree of recovery of the skin state under suction and release . The meaning diagram of Uf, Ua...

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PUM

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Abstract

Provided are an AGE breakdown agent and an agent for preventing, inhibiting, or ameliorating skin deterioration stemming from AGE buildup, said agents containing, as an active ingredient, either: (i) an unsaturated fatty acid and / or a pharmaceutically-permitted salt, ester, amide, and / or glyceride thereof; or (ii) a vegetable oil (evening primrose oil, pequi oil, meadowfoam oil, shea oil, etc.) that contains an unsaturated fatty acid and / or a glyceride thereof. An agent which contains either (i) or (ii), in addition to lactic acid, glycolic acid, salicylic acid, malic acid, citric acid, phytic acid, and / or a pharmaceutically-permitted salt of one or more of said acids, is a more effective agent for preventing, inhibiting, or ameliorating skin deterioration stemming from AGE buildup.

Description

technical field [0001] The present invention relates to an advanced glycation end product degrading agent used as a cosmetic material composition or a food composition, and an agent for preventing, suppressing or improving skin aging caused by accumulation of advanced glycation end product. Background technique [0002] Between reducing sugars such as glucose and proteins, a glycation reaction (Maillard reaction) occurs and glycation products are formed. The glycation reaction of protein also occurs in the living body. When the high blood sugar state is sustained due to diabetes or other reasons or the decomposition reaction is difficult due to aging, the glycation product tends to be formed, the function of the protein is destroyed, or the glycation product is accumulated. The glycation products eventually form glycation end products (advanced glycation end products; hereinafter sometimes simply referred to as "AGEs"), but the generation of AGEs is an irreversible reaction....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/36A61K8/37A61K8/97A61K31/201A61K31/23A61P17/00A61P43/00A61Q19/08A23L1/30
CPCA23L33/115A61K8/36A61K8/922A61K31/201A61K31/23A61P17/00A61P43/00A61Q19/02A61Q19/08A61Q19/10
Inventor 林裕也武田幸惠丹羽岳志稻冈贤
Owner ROHTO PHARM CO LTD
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