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Surfactant, preparation method thereof, and related intermediate and its application

A technology for surfactants and amino acids, which is applied in the preparation method thereof and the intermediates involved, in the field of surfactants, achieves the effects of good foaming and emulsifying properties, good biodegradation properties and mild action

Active Publication Date: 2014-09-17
NANJING HUASHI NEW MATERIAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Clinical trials have also been done on patients with human spots and skin eczema, and no abnormalities were found

Method used

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  • Surfactant, preparation method thereof, and related intermediate and its application
  • Surfactant, preparation method thereof, and related intermediate and its application
  • Surfactant, preparation method thereof, and related intermediate and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] The preparation of embodiment 1 n-butyryl chloride (3a)

[0055]

[0056] In a three-necked flask equipped with a thermometer and a reflux condenser, heat 60 mL of thionyl chloride to reflux, add 89 g of n-butyric acid dropwise, drop it for about 3 hours, then reflux for 2 hours, distill at atmospheric pressure, and collect fractions at 100-105 ° C. About 100 g of n-butyryl chloride (3a) was obtained.

Embodiment 2

[0057] The preparation of embodiment 2N-n-butyryl glutamic acid (5a)

[0058]

[0059] In a dry 1L three-necked flask, add 16.9g of sodium glutamate and 60mL of water, cool in an ice-salt bath to about 0-5°C, adjust the pH value to 10.5 with 20% aqueous sodium hydroxide solution, and slowly add the solution prepared in Example 1 dropwise. The obtained n-butyryl chloride was 10.6g, and kept the internal temperature at 0-5°C, dripped for about 2.5h, continued to stir for 1.5h, removed the ice-water bath, naturally warmed to room temperature, continued the reaction for 1h, and then cooled to 0-5°C, After adjusting the pH value to 3-4, a large amount of solids were precipitated, filtered by suction, and dried to obtain 20.5 g of N-n-butyryl glutamic acid (5a) as a white powdery solid.

Embodiment 3

[0060] The preparation of embodiment 3N-n-butyrylglutamyl chloride (6a)

[0061]

[0062] In a dry 1L round bottom flask, add 12.5g of N-n-butyrylglutamic acid (5a), 60mL of thionyl chloride, and a catalytic amount of DMF, and react at 40-50°C for 6-8h until no acidic gas escapes to obtain Brown solution, excess thionyl chloride was distilled off under reduced pressure to obtain 12.1 g of n-butylglutamyl chloride (6a).

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Abstract

The invention belongs to the field of fine chemical industry, and discloses a surfactant, its preparation method, involved intermediates and its application. The structural formula of this type of surfactant is as follows: the preparation method is to first amidate glutamic acid, then couple it with symmetrical aminoacetic acid to form symmetrical alkanoyl glutamyl glycine, and then neutralize to obtain the target product. The surfactant of the present invention has the characteristics of environmental protection, mildness, and high efficiency. Because it has a chemical structure similar to peptides, it also has a good repair function for skin and hair, and can be widely used in the fields of daily chemicals, food, medicine, etc. , especially as a surfactant in daily chemicals.

Description

technical field [0001] The present invention relates to a kind of surfactant, its preparation method and related intermediate and its application, especially relates to bis(N-alkyl-L-glutamyl) alkyl diglycine, its preparation method and related intermediate body, and the application of the surfactant in daily chemical products. Background technique [0002] Amino acid surfactants are surfactants based on biological substances. Their research began more than 40 years ago, and they were mainly used as preservatives in medicine and cosmetics. The research found that they have good antiviral properties. As a class of surfactants with high safety, good biodegradability and excellent effect, due to its incomparable characteristics, it has attracted more and more attention and attention. For its simplest and most common structure, see figure 1 [0003] Amino acid-based surfactants have good biodegradability. These surfactants have good biodegradability. Studies have shown that ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01F17/28C07C237/22C07C231/12C07C231/02C11D1/10A61K8/44A61Q5/02C09K23/28
Inventor 苏桂珍史鲁秋李华山
Owner NANJING HUASHI NEW MATERIAL CO LTD
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