Cocktail antibody for determining histological type of carcinoma, determination kit and determination method

A cocktail and histological technology, applied in the field of kits for determining the histological type of non-small cell lung cancer, can solve the problems of non-squamous cell carcinoma markers and the positive expression rate of p63 is not 100%, and achieve the effect of simplifying the determination

Inactive Publication Date: 2012-04-04
UNIVERSITY OF TOYAMA
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  • Abstract
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Problems solved by technology

[0010] However, because CK18 is positive for both adenocarcinoma and squamous cell carcinoma, it is not suitable as a marker for squamous cell carcinoma
[0011] In addition, the positive expression rate of p63 in squamous cell carcinoma is not 100%

Method used

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  • Cocktail antibody for determining histological type of carcinoma, determination kit and determination method
  • Cocktail antibody for determining histological type of carcinoma, determination kit and determination method
  • Cocktail antibody for determining histological type of carcinoma, determination kit and determination method

Examples

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Embodiment 1

[0091] 1. Selection of specific immunohistochemical markers for squamous cell carcinoma and adenocarcinoma of non-small cell lung cancer

[0092] (1) Candidate markers shown in Table 1 were tested for squamous cell carcinoma (5 cases) and adenocarcinoma (7 cases), keratin 7 (CK7), keratin 14 (CK14), Napsin- A, TTF-1, p63 as antibody cocktail (see figure 1 ) candidate markers.

[0093] Table 1

[0094] candidate marker

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Abstract

Disclosed are a cocktail antibody, which is useful in determining the histological type of carcinoma, and a determination method using the same. Also disclosed is a determination kit. A cocktail antibody to be used for determining the histological type of lung carcinoma, characterized by comprising a combination of ADC cocktail antibody, which undergoes antigen-antibody reactions with Napsin-A localizing in the cytoplasm of adenocarcinoma and TTF-1 localizing in the cell nucleus thereof, with SCC cocktail antibody, which undergoes antigen-antibody reactions with CK14 localizing in the cytoplasm of squamous cell carcinoma and p63 localizing in the cell nucleus thereof.

Description

technical field [0001] The invention relates to a method for determining the histological type of cancer by immunohistochemistry (IHC). In particular, it relates to an antibody cocktail (cocktail antibody) effective for determining the histology of non-small cell lung cancer, a method for determining the histology of non-small cell lung cancer by using the antibody cocktail, and a kit for determining the histology of non-small cell lung cancer. Background technique [0002] It is estimated that one million or more people worldwide die from lung cancer every year. Histologically, lung cancer is divided into small cell lung cancer (SCLC, Small Cell Lung Carcinoma) or non-small cell lung cancer (NSCLC, Non-Small Cell Lung Carcinoma). Non-small cell lung cancer is further divided into adenocarcinoma (ADC, Adenocarcinoma), squamous cell carcinoma (SCC, Squamous Cell Carcinoma) and large cell carcinoma, which is undifferentiated non-small cell lung cancer. [0003] Pemetrexed an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K16/30G01N33/48G01N33/574
CPCG01N33/57423C07K16/40C07K16/18
Inventor 福岡顺也谷洋一
Owner UNIVERSITY OF TOYAMA
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