Ultramicro powder epimedium constant-temperature preparation method

A technology of epimedium and ultrafine powder, which is applied in the direction of pharmaceutical formulas, medical preparations containing active ingredients, plant raw materials, etc., and can solve the constraints of large-scale production of veterinary traditional Chinese medicine ultrafine powder, low bioavailability, and poor fluidity and other problems, to achieve the effect of being suitable for large-scale industrial production, improving the cell wall breaking rate, and simplifying the preparation process

Active Publication Date: 2013-12-04
HENAN KANGXING PHARMA +1
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Epimedium currently used as a feed additive for livestock and poultry is mostly coarsely crushed powder, which has the disadvantages of large dosage, coarse dosage form, and poor appearance. The active ingredients cannot be fully released, and the bioavailability is low, which seriously affects the quality and therapeutic effect of traditional Chinese medicine.
[0004] Traditional Chinese medicine ultrafine pulverization technology is an update and development of traditional pulverization technology. It not only retains the advantages of traditional Chinese medicine preparation technology, but also injects new vitality into the modern production of Chinese medicine. It has broad application prospects, but there are still some problems in actual production. Problems and problems: (1) Low production efficiency and high energy consumption are the main factors restricting the large-scale production of veterinary traditional Chinese medicine ultrafine powder
In the traditional closed-circuit crushing process, when most of the materials have reached the fineness requirements, there is always a small part of coarse powder mixed in it. To further crush this part of coarse powder to the required particle size, it is necessary to greatly prolong the crushing time, so that the crushing The efficiency is reduced and the energy consumption is greatly increased; (2) There is a difference in particle size uniformity of the material after classification in winnowing classification and classification wheel classification, which greatly affects the production quality of Chinese veterinary compound superfine powder, especially when it is used in animal drinking water or granules When the material is used, it is difficult to meet the requirements due to the existence of a large number of unbroken cells
(3) In the traditional unidirectional airflow screening, when Chinese medicine is ultrafinely pulverized, as the particle size decreases, the surface area and surface energy of the material particles increase, the adsorption increases, the fluidity becomes poor, and it is easy to aggregate into large particles It is difficult to sieve and classify powders with a fineness of more than 200 mesh
The existence of the above factors has seriously affected the standardization and large-scale production of Chinese veterinary drug superfine powder, as well as the promotion and use in veterinary clinics.

Method used

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Embodiment Construction

[0027] Such as figure 1 , 2 Shown, the normal temperature preparation method of superfine powder Epimedium of the present invention comprises the following steps:

[0028] The first step is to select high-quality Epimedium with few stems, many leaves, yellow-green color, and not broken. Among them, the quality of Epimedium lobularis produced in Northwest China is the best, and the content of Epimedium rickets is not less than 1.0%. Air-dried or oven-dried to a moisture content of ≤10%;

[0029] In the second step, the Epimedium is pulverized at 20°C to 25°C to obtain a coarse powder with a particle size of 60-80 mesh;

[0030] The third step, at first turn on the powder conveying fan 15, the induced draft fan 5, the blower 11, and the driving motor 8. The blowing pressure of the powder conveying fan 15 is 24kpa, and the blowing volume is 150m 3 / h; the induced air pressure of the induced draft fan 5 is 1000pa, and the induced air volume is 3000m 3 / h; the blast pressure ...

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Abstract

The invention discloses an ultramicro powder epimedium constant-temperature preparation method. The preparation method comprises the following steps of: taking the traditional Chinese medicine of epimedium, cleaning, and drying until the content of moisture is less than or equal to 10%; milling the epimedium under the room temperature to obtain coarse powder with the particle size of 60-80 meshes; placing the obtained coarse powder in a rod mill to be milled to enter a dedicated bidirectional air flow screening machine through the air to be subject to 500-mesh screening, obtaining powder with the particle size being less than or equal to 25 microns; and transmitting the powder into a cyclone collector through the air flow produced by a draught fan to obtain the finished product of the ultramicro powder epimedium, wherein the powder which is not subject to the 500-mesh screening is collected by a funnel, and is transmitted into the rod mill through a pipeline to be circulated and milled again. The invention has the advantages that the whole preparation process is carried out under the room temperature, no low temperature or special additional condition is needed, the prepared finished product of the ultramicro powder epimedium has the particle size being less than or equal to 25 microns, the cell wall-broken rate and the bioavailability are greatly improved, and the pharmacological effect of the medicine is strengthened. By the bidirectional air flow screening machine used in the invention, the preparation process of the ultramicro powder epimedium is simplified.

Description

technical field [0001] The invention relates to a veterinary drug additive, in particular to a normal-temperature preparation method of superfine powder epimedium; the invention also relates to a special two-way air flow sieving machine used in the method. Background technique [0002] Chicken and eggs are one of the sources of protein to improve and strengthen human dietary structure. In modern large-scale farming, antibiotics and hormones are generally added to feed to improve the production performance of livestock and poultry. After these drugs are metabolized in the body, they are prone to produce cytotoxic substances. It affects the quality of chicken and eggs, and it is easy to cause pathogenic microorganisms to develop drug resistance, causing problems such as drug residues and environmental pollution, and endangering human health. Traditional Chinese medicine additives have the characteristics of low toxicity, no drug resistance, no drug residue, simple processing a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/296A61P37/04A61P15/00A23K1/16A23K1/18B02C23/20
Inventor 张国祖孔维丽马霞刘瑞丽李秋霞
Owner HENAN KANGXING PHARMA
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