Special reaction kettle for synthesizing vincamine intermediate vinblastine formin

Abstract

The invention relates to a special reaction kettle for synthesizing vincamine intermediate vinblastine forming, which comprises a kettle rack, a kettle erected on the kettle rack and a stirring device, the kettle comprises a kettle body and a kettle cover which is hermetically connected with the kettle body, a material outlet is provided at the lower part of the kettle body, a material inlet is provided on the kettle cover, insulation jackets of the steam inlet and condensed water outlet are provided outside the kettle body, particularly, the stirring device is a magnetic stirring device, and comprises a magnetic device arranged at the lower part of the kettle body and a magnetic stir bar which is in the kettle body and rotated by driving of the magnetic device. The reaction kettle of the invention uses the magnetic stirring device to replace traditional mechanical stirring, the reaction kettle has good seal performance and can satisfy the sealing requirement of synthesizing the reaction kettle by catalytic hydrogenation. Simultaneously, the magnetic stirring device can provide the required stirring force for the catalytic hydrogenation reaction, compared with the mechanical stirring mode, the reaction kettle of the present invention has lower energy consumption and is in favor of reducing the production cost.

Description

technical field [0001] The invention relates to a special reaction kettle for synthesizing a vincamine intermediate, vinblastamine. Background technique [0002] Vincamine is an alkaloid with a ivoryne structure and has strong physiological activity. Early foreign studies focused on its hypotensive activity. Because it can penetrate the blood-brain barrier, it was later found that it has a good effect on dilating blood vessels and increasing cerebral blood flow, but has no effect on the heart, blood vessels, and blood pressure. It is currently the first-line drug for the treatment of cerebral ischemia, and its clinical indications include cerebrovascular disorders, cerebral embolism, cerebral thrombosis, and hemorrhagic sequelae. The curative effect on cerebral arteriosclerosis is stronger than hydroergot and papaverine. [0003] Chinese Invention Patent Publication CN 102108082A discloses a semi-synthetic process for vincamine, which uses tabonin as a raw material to prep...

AI Technical Summary

Problems solved by technology

In the traditional reactor, the stirring device uses a connecting shaft to connect the reducer and the agitator, and at the same time uses a mechanical seal to seal the connection between the connecting shaft and the reducer. During long-term work, the sealing performance is getting worse and worse, which cannot meet the requirements of catalytic acceleration. Sealing requirements required for hydrogen synthesis of Changchun Fomin

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