Folic acid production method for controlling content of technical pteroic acid

A production method and folic acid technology, applied in the direction of organic chemistry and the like, can solve the problems of increased production cost of folic acid, reduced yield of folic acid, difficulties and the like

Active Publication Date: 2012-05-02
JIHENG PHARMA HENGSHUI CITY
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Problems solved by technology

And the folic acid that above-mentioned traditional method produces at present, especially in the folic acid finished product that obtains by adopting sulfuric acid to carry out the technology of acid dissolving, the content of impurity pteroic acid in the folic acid finished product often does not meet this requirement, and because the structure of folic acid is composed of pteroic acid ( pteroic acid) and glutamic acid, althoug

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Embodiment Construction

[0023] In order to reduce the content of pteroic acid in the finished folic acid, we conducted in-depth research on the entire production process of folic acid, and found that part of the pteroic acid contained in the finished product of folic acid appeared in the process of crude product preparation, but only a small part, Most of the pteroic acid appears when it dissolves in acid.

[0024] Based on this understanding, we focused on the technology of controlling the content of pteroic acid on the production of crude products and the research on the acid-dissolving process, especially the acid-dissolving process. Finally found the problem, that is, the concentration of dilute sulfuric acid was too high during the acid-dissolved water analysis process of the crude product, causing a part of folic acid to be oxidized into pteroic acid. Since the oxidation ability of sulfuric acid is related to its acid concentration, under normal circumstances, the acid concentration The higher ...

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Abstract

The invention provides a folic acid production method for controlling the content of technical pteroic acid and is characterized in that the folic acid production method comprises the following processing steps of: a crude product production step of using an intermediate for the folic acid production to prepare a folic acid crude product; an acid dissolution step of dissolving the folic acid crude product in an acid dissolution elutriation container by using a dilute sulfuric acid solution with the concentration of 25%-35% and carrying out elutriation and press filtration on the dissolved folic acid crude product to obtain an acid extract; an alkali dissolution and refining step of carrying out alkali dissolution on the acid extract by using alkali lye to obtain an alkali dissolution filtrate and refining the alkali dissolution filtrate for salt formation by using dilute acid so as to obtain the folic acid finished product. By reducing the concentration of dilute sulfuric acid, folic acid (the content of impurity technical pteroic acid is less than or equal to 0.6%) which accords with the requirement of European pharmacopeia is produced, and the production cost of folic acid is reduced.

Description

technical field [0001] The invention relates to a folic acid production method, in particular to a folic acid production method for controlling pteroic acid content in folic acid finished products during the folic acid production process. Background technique [0002] Folic acid (C 19 h 19 N 7 o 6 ) belongs to the basic variety of vitamins, is an anti-anemia drug, and is used in fields such as feed medicine and food. Folic acid is generally a light orange-yellow crystal or flake, carbonized and darkened at about 250°C, and easily soluble in ethanol, carbonated alkali solution, etc. [0003] Folic acid is named after its rich content in the green leaves of plants. Among the animal tissues, the liver contains the most abundant folic acid. At first, it was extracted from the liver, but now it is mostly produced by synthetic methods (refer to the Chinese invention patent application with the publication numbers CN101973995A and the Chinese invention patents with the announ...

Claims

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Application Information

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IPC IPC(8): C07D475/04
Inventor 刘晓莲徐亚威马胜义贾树红张志强陈剑芳刘向军蔡颂公辛秀彪张磊
Owner JIHENG PHARMA HENGSHUI CITY
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