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Treatment of cancer using photodynamic therapy

A cancerous and tissue-based technology, applied in photodynamic therapy, therapy, phototherapy, etc., can solve problems such as tissue damage, insufficient penetration depth, skin phototoxicity, etc.

Inactive Publication Date: 2012-05-23
HEALTH RES INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are problems associated with their application, including skin phototoxicity, normal tissue damage due to the PDT treatment itself, and insufficient penetration depth

Method used

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  • Treatment of cancer using photodynamic therapy
  • Treatment of cancer using photodynamic therapy

Examples

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example 1

[0044] A 65-year-old man presented with squamous cell carcinoma of his larynx. He declined surgery and radiation therapy and opted for photodynamic therapy treatment with HPPH (2-(1-hexylethoxy)-2-desvinylpyropheophorbide-a derivative). He was given 4mg / m 2 (approximately 0.1 mg / kg) was infused with HPPH over one hour. The following day he received 665nm athermal low-energy laser treatment (150mw / cm) to activate the photodynamic process. Light is transmitted through a single silica fiber that passes through the laryngoscope. He received 665nm, 50J / cm light for 5.5 minutes. He developed temporary edema and hoarseness, which resolved completely within the first 30 days of follow-up examination after treatment. He did not develop a skin photosensitivity reaction. At 3 months of the second follow-up examination, he was found to be in complete response to treatment. No effects on normal tissue were noted.

example 2

[0046] A 45-year-old man presented with squamous cell carcinoma of the floor of the mouth. He opted for photodynamic therapy with HPPH (2-(1-hexylethoxy)-2-desvinylpyropheophorbide-a derivative) rather than surgery or radiation therapy. He was injected with 4mg / m 2 HPPH. The following day he received 665nm athermal low-energy laser treatment (150mw / cm) to activate the photodynamic process. Light is transmitted through a single silica fiber that passes through the laryngoscope. He was exposed to 665nm, 50J / cm light for 5.5 minutes. He developed transient moderate pain at the treated site, which was managed with analgesics. This resolved within 30 days of the post-treatment checkup. He did not develop a skin photosensitivity reaction. At 6 months of follow-up examination, he was found to be in complete response to treatment, as confirmed by biopsy. No effects on normal tissue were noted.

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Abstract

A method for treatment of cancerous tissue in the upper respiratory system including the steps of: injecting HPPH in a physiologically compatible medium into a patient having the cancerous tissue at a level of 3 through 5 mg / m2 of body surface area, waiting for a time period of 24 through 60 hours to permit preferential absorption of the HPPH into the cancerous tissue, and exposing the cancerous tissue to light at a wavelength of about 665+-5 nm at an energy of about 75 to about 200 Joules / cm.

Description

[0001] Cross references to related patent applications [0002] This application claims priority from US Patent Application Serial No. 12 / 462,606, filed August 6,2009. [0003] Statement Regarding Federally Funded Research [0004] This invention was made with support from the National Institute of Health under grant numbers NIH (1R21 CA109914-01, CA55792 and CAPO155791). The US Government has certain rights in this invention. Background of the invention [0005] The National Cancer Institute estimates that in 2007 there will be 11,300 new cases of laryngeal cancer and 3,660 deaths. In addition, it is predicted that there will be 34,360 new cases of oropharyngeal cancer in 2007 (2007 NCI Surveillance, Epidemiology, and End Results Program). Pfister et al have published the American Society of Clinical Oncology application guideline on laryngeal preservation in the treatment of laryngeal cancer. These were developed by an expert group by examining the literature available i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M37/00
CPCA61N2005/0604A61N5/0601A61N5/062A61N2005/0662A61K41/0057A61N2005/0659A61K41/0071A61K9/0019A61K31/409A61M37/00
Inventor 拉温德拉·K·潘迪托马斯·J·多尔蒂威廉·波特
Owner HEALTH RES INC