Method for preparing sodium gluconate through adopting semicontinuous fermentation technology

A technology of sodium gluconate and fermentation process, which is applied in the field of preparing sodium gluconate by semi-continuous fermentation process, which can solve the problems of no catalytic activity, low utilization rate of equipment, prolonged reaction time, etc., and achieve the reduction of steam sterilization times and continuous production Strong durability and stable product quality

Active Publication Date: 2012-06-27
黑龙江中瑯生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This technology improves how much sugars can be added during alcoholic brewing processes without sacrificing taste or flavor characteristics for better results. It also increases the amount of water needed per unit volume while maintaining consistently high yields through efficient heat treatment methods that reduce energy usage. Additionally, it provides stronger control over producing products after extraction from their container's walls.

Problems solved by technology

This patented technical problem addressed in this patents relates to improving the manufacturing processes involved in making sodium gamma ammonia dicarboxydimethanesulfonatobutane diacetone succmate (NaMUDA), commonly called beta hydrocortisulphornium adductsive ion exchange reservoir cells (β-CNES). Current technologies involve expensive steps like filtrations, precipitation, centrifugal separators, addition reactor vessels, adjustments during synthesis, and various refining techniques including high pressure homogenizers and membrane filters. Additionally, there are limitations on how long the required production cycle takes due to these factors.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] (1) Put the fermentation medium into the fermenter, insert the Aspergillus niger spore liquid (China Industrial Microorganism Strain Management and Preservation Center, CICC40417), and incubate:

[0022] The cultivation time is 15 hours, the tank pressure is controlled at 0.22MPa, the temperature is controlled at 35°C, the pH value is controlled at 6.8 within 0-12h, and 6.4 after 12h, and the ventilation ratio is controlled at 1.6 within 0-4h, 4-8h Control it within 1.8, and control it at 2.2 after 8 hours;

[0023] (2) Release 50% of the culture solution and supplement the same volume of fresh medium for cultivation:

[0024] The cultivation time is 6 hours, the tank pressure is controlled at 0.14MPa, the temperature is controlled at 33°C, the pH value is controlled at 6.5 within 0-4h, 6.0 after 4h, and the ventilation ratio is controlled at 1.0;

[0025] (3) step (2) is carried out in a cycle, and a total cycle is carried out 6 times;

[0026] (4) put the tank.

[...

Embodiment 2

[0030] (1) Put the fermentation medium into the fermenter, insert the Aspergillus niger spore liquid (China Industrial Microorganism Strain Management and Preservation Center, CICC40424), and incubate:

[0031] The cultivation time is 18 hours, the tank pressure is controlled at 0.18MPa, the temperature is controlled at 32°C, the pH value is controlled at 6.5 within 0-12h, and 6.0 after 12h, and the ventilation ratio is controlled at 1.5 within 0-4h, 4-8h Control it within 1.6, and control it at 1.8 after 8 hours;

[0032] (2) Release 20% of the culture solution and supplement the same volume of fresh medium for cultivation:

[0033] The cultivation time is 4.5 hours, the tank pressure is controlled at 0.16MPa, the temperature is controlled at 38°C, the pH value is controlled at 6.7 within 0-4h, 6.4 after 4h, and the ventilation ratio is controlled at 1.2;

[0034] (5) step (2) is carried out in a cycle, and a total cycle is carried out 9 times;

[0035] (6) put the tank.

...

Embodiment 3

[0039] (1) Put the fermentation medium into the fermenter, insert the Aspergillus niger spore liquid (China Industrial Microorganism Strain Management and Preservation Center, CICC40405), and incubate:

[0040] The cultivation time is 16 hours, the tank pressure is controlled at 0.20MPa, the temperature is controlled at 34°C, the pH value is controlled at 6.7 within 0-12h, and 6.2 after 12h, and the ventilation ratio is controlled at 1.5 within 0-4h, 4-8h Control it within 1.7, and control it at 2.0 after 8 hours;

[0041] (2) Release 30% of the culture solution and supplement the same volume of fresh medium for cultivation:

[0042] The cultivation time is 5.5 hours, the tank pressure is controlled at 0.15MPa, the temperature is controlled at 35°C, the pH value is controlled at 6.6 within 0-4h, 6.2 after 4h, and the ventilation ratio is controlled at 1.1;

[0043] (7) step (2) is carried out in a cycle, and a total cycle is carried out 7 times;

[0044] (8) put the tank.

...

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PUM

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Abstract

The invention relates to a method for preparing sodium gluconate through adopting a semicontinuous fermentation technology. The method comprises the following steps: 1, putting a fermentation medium into a fermentation tank, accessing an Aspergillus niger spore liquid, and carrying out temperature maintenance culture; 2, discharging 20-50% of the obtained culture solution, and simultaneously supplementing the fresh medium which is isometric to the discharged culture solution to culture; 3, circulatingly carrying out step 2; and 4, discharging the obtained material from the tank. Compared withtraditional fermentation technologies, the preparation method of the invention, which adopts the fermentation medium with the sugar concentration of 5-10% higher than sugar concentrations of traditional fermentation mediums, has the advantages of improvement of the content of sodium gluconate in the total fermentation liquid, reduction of the steam disinfection frequency of the fermentation tank and a pipeline thereof, steam consumption reduction, strong production continuity, guarantee of the uniformity and the continuity of post-extraction production, and finished product quality stability guarantee.

Description

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Claims

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Application Information

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Owner 黑龙江中瑯生物科技有限公司
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