Method for preparing sodium gluconate through adopting semicontinuous fermentation technology

Abstract

The invention relates to a method for preparing sodium gluconate through adopting a semicontinuous fermentation technology. The method comprises the following steps: 1, putting a fermentation medium into a fermentation tank, accessing an Aspergillus niger spore liquid, and carrying out temperature maintenance culture; 2, discharging 20-50% of the obtained culture solution, and simultaneously supplementing the fresh medium which is isometric to the discharged culture solution to culture; 3, circulatingly carrying out step 2; and 4, discharging the obtained material from the tank. Compared with traditional fermentation technologies, the preparation method of the invention, which adopts the fermentation medium with the sugar concentration of 5-10% higher than sugar concentrations of traditional fermentation mediums, has the advantages of improvement of the content of sodium gluconate in the total fermentation liquid, reduction of the steam disinfection frequency of the fermentation tank and a pipeline thereof, steam consumption reduction, strong production continuity, guarantee of the uniformity and the continuity of post-extraction production, and finished product quality stability guarantee.

Description

technical field [0001] The invention relates to a method for preparing sodium gluconate, in particular to a method for preparing sodium gluconate using a semi-continuous fermentation process. Background technique [0002] Sodium gluconate, also known as sodium pentahydroxyhexanoate, is a white or light yellow crystalline powder, easily soluble in water, slightly soluble in alcohol, and insoluble in ether. Its molecular formula is C 6 h 11 o 7 Na, the relative molecular weight is 218.14. Sodium gluconate is a polyhydroxy organic acid salt with a wide range of uses. Due to its non-toxicity and wide source of raw materials, it has a wide range of uses in chemical, food, medicine, light industry and other industries, such as being used as an acid-base balance agent , water quality stabilizer, surface cleaning agent, cement participation agent, etc. [0003] At present, the preparation methods of sodium gluconate mainly include catalytic oxidation method and traditional biol...

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Problems solved by technology

[0007] However, the production of sodium gluconate by the catalytic oxidation method will produce by-products such as glucose dialdehyde and glucuronic acid, and after the catalyst used is recycled for a certain number of times, the catalytic efficiency will decrease, the conversion rate of glucose will be reduced, and the reaction time will be prolonged or even basically There is no catalytic activity, and the replacement of the catalyst will increase the production cost accordingly; while the traditional biological fermentation method to produce sodium gluconate also has the disadvantages of low equipment utilization, large steam consumption, and weak production continuity.