Visible blood glucose test strip and preparation method thereof

A blood glucose test strip and an integrated technology, applied in the field of visual blood glucose test strips and their preparation, can solve the problems of complex production process of printed circuit, complex structure of preparation process and test strip, high price, etc., and achieve rapid detection of blood glucose value and good biodegradation. The effect of sex, low price

Inactive Publication Date: 2012-06-27
TIANJIN UNIVERSITY OF SCIENCE AND TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the complex manufacturing process of the printed circuit, the blood glucose test strips based on plastic have the defects of complex preparation process and test strip structure and high price

Method used

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  • Visible blood glucose test strip and preparation method thereof
  • Visible blood glucose test strip and preparation method thereof
  • Visible blood glucose test strip and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] A visual blood glucose test paper, which is composed of an impregnated processed paper substrate 1 and a Millipore nanofiltration membrane 3 coated with an adhesive 2 on the bottom surface, wherein:

[0049] The impregnated processed paper substrate 1 is made of base paper made from one or more pulps of bleached chemical pulp, bleached chemical mechanical pulp and bleached mechanical pulp, with a basis weight of 20 g / m2 ~250 g / m 2 Paper, the present embodiment selects the quantification that is made of bleached chemical pulp to be 40 g / m 2 Paper;

[0050] The bottom surface is coated with the Millipore nanofiltration membrane 2 of adhesive 2, wherein: the adhesive 2 is 3 g / m 2 ~10 g / m 2 Polyvinyl alcohol binder, or 3 g / m 2 ~10 g / m 2 Gelatin binder, or 2 g / m 2 ~ 6g / m 2 Vinyl acetate adhesive, this embodiment chooses 3 g / m 2 Polyvinyl alcohol adhesive, the Millipore nanofiltration membrane 3 is a Millipore 150 nm filter membrane with a pore size less than 500 nm an...

Embodiment 2

[0071] Repeat the same steps as described in Example 1, but the difference is the concentration of the liquid diffusion control agent used in the preparation of the impregnating agent solution, the amount of enzyme and the buffer solution and consumption for adjusting the pH of the impregnating solution:

[0072] The liquid diffusion control agent is 2.0 ml of 3% guar gum aqueous solution;

[0073] 1.5 ml enzymes (16.2 mg glucose oxidase and 1.2 mg horseradish peroxidase per 10 ml enzyme mix solution);

[0074] The buffer solution for adjusting the pH of the impregnating agent solution is 11.5 ml of citric acid / sodium citrate buffer solution.

Embodiment 3

[0076] Carry out embodiment 2 repeatedly by described same step, just difference is the buffer solution and the consumption of adjusting impregnating agent solution pH used in the impregnating agent solution preparation:

[0077] The buffer solution for adjusting the pH of the impregnating agent solution is 11.5 ml malic acid / sodium malate buffer solution.

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Abstract

The invention discloses a visible blood glucose test strip and a preparation method thereof. The visible blood glucose test strip is structurally formed by compounding saturating paper base materials and Millipore nano filter membrane with the bottom face being coated with adhesive. The preparation method comprises the following steps: preparing impregnant solution, preparing the saturating paper base materials, and compounding the saturating paper base materials and the Millipore nano filter membrane. When the test strip is used for blood glucose detection, blood is filtered by the membrane, color development reaction of chromogen reagent, assistant color development reagent and H2O2 is utilized, a special electrochemical signal detection device has no need to be used, so that the effect that blood glucose concentration is quickly and conveniently detected can be achieved. Compared with the test strip with polypropylene, polyethylene, polrvinyl chloride and polycarbonate base materials in the prior art, plant fiber paper base materials of the test strip disclosed by the invention are renewable natural resources, and have the advantages of favorable biodegradation and low price, and the test strip disclosed by the invention can be stored for at least three months at room temperature.

Description

[0001] technical field [0002] The invention belongs to the technical field of special paper products, and relates to a blood sugar test paper and a preparation method thereof, in particular to a visual blood sugar test paper and a preparation method thereof. Background technique [0003] Diabetes mellitus is a common metabolic-secretory disease and a group of clinical syndromes caused by the interaction of genetic and environmental factors. Absolute or relative insufficiency of insulin secretion and decreased sensitivity of target tissue cells to insulin lead to a series of metabolic disorders such as sugar, protein, fat, water and electrolytes. Diabetes can be divided into: type 1 diabetes, type 2 diabetes, specific type of diabetes and gestational diabetes. Although the etiology and pathogenesis of various diabetes are different, they all have high blood sugar as the main common feature. [0004] The normal blood sugar concentration of the human body is 0.60-0.95 mg / ml...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/66
Inventor 倪永浩查瑞涛何志斌
Owner TIANJIN UNIVERSITY OF SCIENCE AND TECHNOLOGY
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