Application of furocoumarin compounds for preparing vasodilators

A furanocoumarin, vasodilation technology, applied in the directions of active ingredients of heterocyclic compounds, drug combinations, cardiovascular system diseases, etc.

Inactive Publication Date: 2012-07-04
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no literature on furanocoumarins for the preparation of vasodilation drugs and their applications

Method used

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  • Application of furocoumarin compounds for preparing vasodilators
  • Application of furocoumarin compounds for preparing vasodilators
  • Application of furocoumarin compounds for preparing vasodilators

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Embodiment Construction

[0021] The present invention will be described in detail below in conjunction with the embodiments.

[0022] 1. Experimental materials

[0023] Animals: male SD rats, weighing 200-300 g, from the Experimental Animal Center of Xi'an Jiaotong University School of Medicine.

[0024] Instrument: DMT vascular tension measurement system (Danish Myo Technology AIS Inc. 610M).

[0025] Reagent: Krebs solution (composition (g / L): 6.954NaCl, 0.343KCl, 1.260NaHCO- 3 , 0.187NaH 2 PO 4 2H 2 O, 0.166CaCl 2 , 0.244MgCl 2 ·6H 2 O, 1.090 glucose, pH=7.2~7.4), dimethylsulfoxide (DMSO, SIGMA.Inc), norepinephrine (NE), U46619.

[0026] 2. Experimental method

[0027] After the rats were killed by neck dislocation, the secondary branches of the mesenteric artery (MA), renal artery (RA), coronary artery (CA), and cerebral basilar artery (BA) were taken out, placed in pre-cooled Krebs solution, and made into 3 mm long branches. Vascular ring specimens are connected with the DMT vascular te...

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Abstract

The invention discloses the application of furocoumarin compounds for preparing vasodilators. The dilating effect of furocoumarin compounds on the mesenteric second-class artery, brain basilar artery, renal artery and coronary artery in rats is investigated by in vitro microvascular tonography. The study result proves that the synthetic furocoumarin compounds can dilate the above four types of blood vessels to different extents and have a potential in vasodilator preparation.

Description

technical field [0001] The invention relates to the technical field of application of furocoumarin compounds, in particular to the application of furocoumarin compounds in the preparation of vasodilation drugs. Background technique [0002] Cardiovascular disease is a common disease in my country today, with a high prevalence rate, and the mortality rate and disability rate caused by related complications are at the forefront of human diseases, which is extremely harmful to human health. Drugs for diseases is the common wish of international biomedical scientists and patients. Vasodilators have important clinical application value and are mainly used for hypertension, myocardial ischemia and cerebral ischemia. In recent years, some active substances with vasodilation effects have been found from natural medicines, but these substances are generally poor in druggability and their mechanism of action is not very clear. [0003] Furanocoumarin compounds exist in a variety of c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/37A61K31/453A61K31/5377A61K31/55A61P9/08
Inventor 贺浪冲贺建宇周楠宋佳贺怀贞张杰王嗣岑卢闻
Owner XI AN JIAOTONG UNIV
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