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Method for decolorizing and purifying paromomycin

A paromomycin and purification method technology, applied in chemical instruments and methods, preparation of sugar derivatives, sugar derivatives, etc., can solve the problems of cumbersome, complex production steps, low yield of paromomycin products, etc. The effect of improving product yield, saving production steps, and saving evaporation and concentration costs

Active Publication Date: 2014-12-10
SANDA FILM SCI & TECH XIAMEN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the production process of paromomycin, a fixed bed of ion exchange resin is used to decolorize the feed liquid first, and then macroporous resin is used to remove impurities. rate is not high

Method used

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  • Method for decolorizing and purifying paromomycin
  • Method for decolorizing and purifying paromomycin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Such as figure 1 As shown in , the continuous moving bed rotating counterclockwise is equipped with 20 201×4 strong basic styrene-based anion exchange resin columns, which are divided into ammonia water analysis area 100, product separation area 200, and impurity separation area 300 in the clockwise direction. And resin regeneration area 200 four partitions, among them, No. 1~6 columns connected in series are ammonia water analysis area 100, No. 7~11 columns connected in series are product separation area 200, No. 12~16 columns connected in series The columns are the impurity separation area 300, the resin regeneration area 400 of the 17th to 20th column, and are successively set up as a water washing area, an alkali regeneration area, a water washing area and an acid regeneration area.

[0027] The inlet of the product separation zone 200 is set at the feed port at the upper end of the No. 7 resin column, and its outlet is set at the discharge port at the lower end of ...

Embodiment 2

[0034] Such as figure 2 As shown in , the continuous moving bed rotating counterclockwise is equipped with 20 201×4 strong basic styrene-based anion exchange resin columns, which are divided into ammonia water analysis area 100, product separation area 200, and impurity separation area 300 in the clockwise direction. And resin regeneration area 200 four partitions, among them, No. 1~6 columns connected in series are ammonia water analysis area 100, No. 7~9 columns connected in series are product separation areas 200, No. 10~16 columns connected in series The columns are the impurity separation area 300, the resin regeneration area 400 of the 17th to 20th column, and are successively set up as a water washing area, an alkali regeneration area, a water washing area and an acid regeneration area.

[0035] The inlet of the product separation zone 200 is set at the feed port at the upper end of the No. 7 resin column, and its outlet is set at the discharge port at the lower end of...

Embodiment 3

[0042] Such as figure 1 As shown in , the continuous moving bed rotating counterclockwise is equipped with 20 201×4 strong basic styrene-based anion exchange resin columns, which are divided into ammonia water analysis area 100, product separation area 200, and impurity separation area 300 in the clockwise direction. And resin regeneration area 200 four partitions, among them, No. 1~6 columns connected in series are ammonia water analysis area 100, No. 7~11 columns connected in series are product separation area 200, No. 12~16 columns connected in series The columns are the impurity separation area 300, the resin regeneration area 400 of the 17th to 20th column, and are successively set up as a water washing area, an alkali regeneration area, a water washing area and an acid regeneration area.

[0043] The inlet of the product separation zone 200 is set at the feed port at the upper end of the No. 7 resin column, and its outlet is set at the discharge port at the lower end of ...

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Abstract

The invention relates to a method for decolorizing and purifying paromomycin. The method comprises the following steps of: 1) sequentially dividing a plurality of anion exchange resin columns of an anticlockwise rotating continuous moving bed into an aqueous ammonia resolving area, a product separation area, an impurity separation area and a resin regeneration area in a clockwise direction; 2) delivering the liquid discharged from the aqueous ammonia resolving area to a first material tank, delivering the liquid in the first material tank to the product separation area from the inlet of the product separation area, and making the liquid flow to a second material tank from the outlet of the product separation area; 3) supplying a paromomycin mixed solution to be treated to the second material tank, delivering the mixed solution in the second material tank to the impurity separation area from the inlet of the impurity separation area, and making the mixed solution flow out of the outlet of the impurity separation area; and 4) collecting the liquid in the first material tank, and thus obtaining a paromomycin product. A continuous ion exchange technology is used for simultaneous decolorization and impurity removal of the paromomycin mixed solution in the method, so that the production steps are reduced and the yield of the product is improved.

Description

technical field [0001] The invention relates to a method for decolorization and purification, in particular to a method for decolorization and purification of paromomycin. Background technique [0002] Paromomycin, also known as Paromomycin, Paromomycin or PRM, is an aminoglycoside broad-spectrum antibiotic with a similar antibacterial spectrum to neomycin, and is characterized by its strong anti-amoeba It has a good antibacterial effect on Gram-negative bacilli and acid-fast bacilli. In addition, it is effective against tapeworms. Clinically, it is mainly used for intestinal amoebiasis, bacillary dysentery and bacterial intestinal infection, and can also treat tapeworm disease. In the production process of paromomycin, a fixed bed of ion exchange resin is used to decolorize the feed liquid first, and then macroporous resin is used to remove impurities. The rate is not high. Contents of the invention [0003] The purpose of the present invention is to provide a method f...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07H15/232C07H1/06
Inventor 杜明华方富林林丽华蓝伟光林雄水
Owner SANDA FILM SCI & TECH XIAMEN
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