Method for removing residual pharmaceutical ingredients in oxytetracycline pharmaceutical dregs by ultrasonic wave

A technology of residual drugs and oxytetracycline, applied in the removal of solid waste, etc., can solve the problems of high process conditions, high concentration of hydrochloric acid, complicated process, etc., and achieve rapid treatment process, no secondary pollution, and mild degradation conditions Effect

Inactive Publication Date: 2014-01-22
HEBEI UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The process conditions are demanding, the process is complicated and the cycle is long, and the waste residue after protein removal needs to be treated
The other is to use chemical methods to treat the dregs of oxytetracycline (ZL200710185390.4), which takes a long time, the concentration of hydrochloric acid is high, and the amount is large, and methanol is used in the treatment process, so there will inevitably be methanol residues

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Take 50 grams of oxytetracycline wet drug residue and put it in a beaker, place it in a water bath and heat it to 70 ℃-75 ℃ for 10 minutes, cool it to room temperature, add 25 mL of 0.5 mol / L hydrochloric acid solution, stir and mix evenly, and measure the pH to be 0.5; The uniform dregs are placed in the ultrasonic instrument, and the ultrasonic frequency is 20kHz and the sound intensity is 1W / cm 2 When the filtrate was treated for 30min, it was centrifuged and filtered, and the filtrate was recovered for reuse as a pH regulator. The filter residue was adjusted to pH 4.5 with calcium oxide, and dried in a drying oven at 90°C for 30min; In the treated oxytetracycline residues, the residual oxytetracycline content decreased from 0.57% to 0.07%, the removal rate was 87.7%, and the crude protein content decreased from 40.3% to 36.9%, a decrease of 8.4%.

Embodiment 2

[0024] Take 50 grams of oxytetracycline wet slag and put it in a beaker, place it in a water bath and heat it to 70°C-75°C for 20 minutes, cool it to room temperature, add 20 mL of 0.5mol / L hydrochloric acid solution, stir and mix evenly, and measure the pH to be 0.6; The uniform dregs are placed in the ultrasonic instrument, and the ultrasonic frequency is 40kHz and the sound intensity is 2W / cm 2 When the filtrate was treated for 10 min, it was centrifuged and filtered, and the filtrate was recovered as a pH regulator for reuse. The filter residue was adjusted to pH 4.5 with calcium oxide, and dried in a drying oven at 90 °C for 30 min; In the treated oxytetracycline residue, the residual oxytetracycline content decreased from 0.57% to 0.055%, the removal rate was 90.3%, and the crude protein content decreased from 40.3% to 36.9%, a decrease of 8.4%.

Embodiment 3

[0026] Take 50 grams of oxytetracycline wet drug residue and put it in a beaker, place it in a water bath and heat it to 70°C-75°C for 10 minutes, cool it to room temperature, add 1 mL of 0.5mol / L hydrochloric acid solution, stir and mix evenly, and measure the pH to be 0.8; The uniform dregs are placed in the ultrasonic instrument, the ultrasonic frequency is 80kHz and the sound intensity is 3.5W / cm 2 When the pH value was adjusted to 4.5 with calcium oxide, the filter residue was adjusted to pH 4.5 and dried at 90°C for 30min; after cooling, it was tested according to the standard of "Veterinary Pharmacopoeia of the People's Republic of China". In the treated oxytetracycline residue, the residual oxytetracycline content decreased from 0.57% to 0.06%, the removal rate was 89.5%, and the crude protein content decreased from 40.3% to 36.9%, a decrease of 8.4%.

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Abstract

The invention discloses a method for removing residual pharmaceutical ingredients in oxytetracycline pharmaceutical dregs by ultrasonic wave, comprising the following steps of: A, heating up oxytetracycline wet pharmaceutical dregs to solidify protein, so that the protein is not influenced by ultrasonic wave; B, cooling the oxytetracycline wet pharmaceutical dregs into normal temperature, adjusting the pH of the oxytetracycline wet pharmaceutical dregs into 0.5-1.0 by hydrochloric acid, and evenly stirring the wet pharmaceutical dregs; and C, putting the evenly-stirred wet pharmaceutical dregs into a container with normal pressure and ultrasonic environment to carry out ultrasonic wave radiation, and degrading and invalidating the oxytetracycline ingredient in the wet pharmaceutical dregs by the acoustic cavitation effect of the ultrasonic wave. The method is quick, low-cost and environment-friendly to treat the oxytetracycline pharmaceutical dregs, and is good in treatment effect, so that the obtained product is heavy in weight and high in use value.

Description

technical field [0001] The invention relates to the technical field of resource utilization, reduction and comprehensive utilization of industrial solid waste, in particular to a method for eliminating residual medicinal components in oxytetracycline dregs by using ultrasonic waves. Background technique [0002] Oxytetracycline is a broad-spectrum antibiotic, a microbial fermentation product, and has strong bacteriostatic effects on some Gram-positive bacteria, negative bacteria and rickettsia. Oxytetracycline is an amphoteric compound that is prone to denaturation under acid and alkali conditions. At present, the domestic production process of oxytetracycline mainly consists of two parts: fermentation and extraction. The microbial fermentation process uses starch, soybean powder cake, dextrin and other nearly 10 kinds of organic substances as raw materials as the carbon source and energy for microbial synthesis; the extraction process is made of oxalic acid. The acidifier ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B09B3/00
Inventor 闫正程琛李庆李文昭杨敬伟陈伟龙张小彬孙宏丽
Owner HEBEI UNIVERSITY
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