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Cell printing self-adaptive inkjet driving control method

A cell printing and self-adaptive technology, applied in tissue cell/virus culture devices, printing devices, biochemical equipment and methods, etc., can solve nozzle clogging, difficulty in ejecting high-viscosity and high-density liquids, and hinder cell Problems such as the realization of printing projects, to achieve the effect of avoiding clogging

Inactive Publication Date: 2012-07-11
XIDIAN UNIV
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AI Technical Summary

Problems solved by technology

At present, most of the cell printing is to load the cultured cells in a clean ink cartridge and use a commercial nozzle to spray. Since this type of nozzle is designed for jetting ink, there are two main problems when spraying biological agents with different physical parameters. One is It is difficult to eject high-viscosity, high-density liquid, and the second is that poor ejection can easily lead to clogging of nozzle holes, which seriously hinders the realization of cell printing engineering

Method used

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  • Cell printing self-adaptive inkjet driving control method
  • Cell printing self-adaptive inkjet driving control method
  • Cell printing self-adaptive inkjet driving control method

Examples

Experimental program
Comparison scheme
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Embodiment Construction

[0064] The specific results and working principle of the piezoelectric nozzle:

[0065] (1) The specific structure of the piezoelectric nozzle

[0066] refer to figure 2 The schematic diagram of the structure of the piezoelectric nozzle shown includes an inkjet liquid tank, an ink jet channel, a nozzle hole and a piezoelectric sheet. One end of the ink jet channel is connected to the nozzle hole, and the other end communicates with the ink jet liquid tank. Electric sheets and piezoelectric sheets are distributed above and below the inkjet channel.

[0067] (2) Working principle of piezoelectric nozzle

[0068] refer to figure 1 , at t 0 At this time, the driver applies a square wave signal with a width of T0 to the piezoelectric sheet, and the voltage causes the piezoelectric sheet to contract, forming a negative pressure in the inkjet channel chamber, and the negative pressure propagates toward the inkjet liquid tank (b); when it reaches At the inkjet liquid tank, becau...

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PUM

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Abstract

The invention belongs to the field of the tissue engineering, and particularly discloses a cell printing self-adaptive inkjet driving control method in which a piezo printhead is used for controlling. The self-adaptive inkjet driving control method is characterized in that an inkjet liquid tank, an inkjet passage, a spray orifice and piezoelectric plates are adopted; one end of the inkjet passageis communicated to the spray orifice and the other end of the inkjet passage is communicated with the inkjet liquid tank; the piezoelectric plates are arranged outside the inkjet passage; and the piezoelectric plates are distributed on and under the inkjet passage. The cell printing self-adaptive inkjet driving control method is used for implementing the jetting of a high-viscosity biological agent and for solving the phenomenon of blocking.

Description

technical field [0001] The invention belongs to the field of tissue engineering, and specifically relates to an adaptive inkjet drive control method for cell printing controlled by a micro piezoelectric nozzle, which is used to realize the injection of high-viscosity biological preparations and solve the clogging phenomenon. Background technique [0002] As a new technology to replace the traditional biodegradable solid scaffold method, cell printing has great development potential in tissue engineering. It uses the principle that cells can self-assemble in developmental biology, just like embryonic tissue forms a functional structure, and a three-dimensional tissue structure can be formed by printing cells layer by layer. Compared with cell shaping based on three-dimensional porous scaffolds, cell printing is computer-assisted, not just relying on the adhesion, proliferation, and differentiation of cells. The paper "Delivery of Human Fibroblast Cells by Piezoelectric Drop-...

Claims

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Application Information

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IPC IPC(8): B41J29/393B41J2/01B41J3/00C12M3/00
Inventor 黄进胡飞飞徐荣泽范建宇
Owner XIDIAN UNIV
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