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Externally applied hydrogel agent and preparation method and application thereof

A hydrogel, gel technology, applied in 3 fields

Active Publication Date: 2012-07-18
HEBEI UNIVERSITY OF SCIENCE AND TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Nonetheless, at present, there are no reports of 3,5-dihydroxy-4-isopropylstilbene topical hydrogels

Method used

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  • Externally applied hydrogel agent and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0148] Example 1: Preparation of an external hydrogel dosage form of 3,5-dihydroxy-4-isopropylstilbene

[0149] The implementation steps of this embodiment are as follows:

[0150] Add 15 parts by weight of carbomer to 80 parts by weight of glycerin, stir and infiltrate to make a paste, then add an appropriate amount of water, and then place it at room temperature overnight to make it fully swell, the particle size of carbomer will not increase, stir Uniformly, then add 10 parts by weight of triethanolamine gelling agent dropwise therein, use 0.5N NaOH solution to adjust the pH to 6.5, make it into a gel, stir evenly; add 25 parts by weight of 3,5-dihydroxy-4-iso Propyl stilbene, 12 parts by weight of chlorocresol antibacterial agent and 20 parts by weight of laurocaprazine transdermal accelerator are dissolved in 400 parts by weight of ethanol solvent B, and the solution obtained is added to the gel , stir evenly, then add water to make the total amount of water reach 600 pa...

Embodiment 2

[0152] Example 2: Preparation of an external hydrogel dosage form of 3,5-dihydroxy-4-isopropylstilbene

[0153] The implementation steps of this embodiment are as follows:

[0154]Add 20 parts by weight of carbomer to 100 parts by weight of propylene glycol, stir and infiltrate to make a paste, then add an appropriate amount of water, and then leave it at room temperature overnight to fully swell until the particle size of carbomer does not increase. Stir Uniform; then 20 parts by weight of 3,5-dihydroxy-4-isopropyl stilbene, 10 parts by weight of mercury bacteriostatic agent and 20 parts by weight of menthol+DMSO (its weight ratio 1: 2) transdermal Accelerator is dissolved in 300 parts by weight of ethanol+isopropanol (volume ratio 2: 1) solvent B, the solution obtained is added in the described gel again, and 20 parts by weight of sodium hydroxide gelling agent is added dropwise therein , use 1.0N NaOH solution to adjust the pH to 6.5, then add water to make the total water...

Embodiment 3

[0156] Example 3: Preparation of an external hydrogel dosage form of 3,5-dihydroxy-4-isopropylstilbene

[0157] This embodiment is carried out in the same manner as Example 1, but the preparation conditions are modified as follows: 5 parts by weight of carbomer, 15 parts by weight of 3,5-dihydroxy-4-isopropyl stilbene, 60 parts by weight of glycerin solvent A, 400 parts by weight of propylene glycol solvent B, 10 parts by weight of benzalkonium chloride antibacterial agent, 40 parts by weight of dimethylacetamide transdermal accelerator, 5 parts by weight of sodium carbonate gelling agent, pH8 and 500 parts by weight of water.

[0158] Through the in vitro transdermal absorption test, the external hydrogel prepared in this example has a cumulative penetration of 3,5-dihydroxy-4-isopropyl stilbene within 12 hours of 608.4 μg / cm 2 .

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Abstract

The invention relates to a 3, 5-dyhydroxy-4-isopropyl diphenylethene externally-applied hydrogel agent and a preparation method and application thereof. The externally-applied hydrogel agent consists of carbomer, 3, 5-dyhydroxy-4-isopropyl diphenylethene, a permeation enhancer, a gel agent, a bacteriostatic agent, solvent and water. The externally-applied hydrogel agent is used for preparing medicine for curing psoriasis or eczema. The externally-applied hydrogel agent has the characteristics of strong adhesive force and easiness in cleaning, the skin permeability can be improved very remarkably and can be improved by 400 times approximately, the biocompatibility is good, the toxicity is low and the curative efficacy exertion of the medicine is greatly facilitated.

Description

【Technical field】 [0001] The invention belongs to the technical field of medicines. More specifically, the present invention relates to a kind of 3,5-dihydroxy-4-isopropyl stilbene external hydrogel, also relates to the preparation method of said external hydrogel, relates to said external hydrogel use of the agent. 【Background technique】 [0002] 3,5-Dihydroxy-4-isopropylstilbene is known to have good antifungal activity. CN200910075295 discloses a clean preparation method of (E)-3,5-dihydroxy-4-isopropylstilbene. The preparation method prepares 3,5-dimethoxy-4-isopropylbenzyl alcohol from 3,5-dihydroxybenzoic acid through methylation and isopropylation (or through isopropylation and methylation) , and then through reduction, halogenation, Wittig-Horner condensation, deprotection and other steps to synthesize the antifungal drug Benzene Moder (E)-3,5-dihydroxy-4-isopropyl stilbene . CN 200910074292 discloses a chitosan-coated slow-release microsphere of 3,5-dihydroxy-4...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K31/047A61K47/32A61P17/00A61P17/06
Inventor 张越于奕峰
Owner HEBEI UNIVERSITY OF SCIENCE AND TECHNOLOGY
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