Application of white flower loropetalum chinense in preparing healing medicine

A technology of extract and white flower, which is applied in the application field of the extract of A. chinensis in the preparation of callus medicine, and achieves the effects of promoting the speed of skin healing, increasing the strength of wound healing, and promoting cell and angiogenesis.

Inactive Publication Date: 2012-07-18
江西徳宇集团
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] There is no report on the preparation of med...

Method used

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  • Application of white flower loropetalum chinense in preparing healing medicine
  • Application of white flower loropetalum chinense in preparing healing medicine
  • Application of white flower loropetalum chinense in preparing healing medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Example 1 Extraction and chemical composition analysis of the crude extract of P.

[0033] 1. Extraction of the crude extract of P. candidum

[0034] Crushing the fresh material of P. chinensis, using the method of enzymatic hydrolysis with combined bacteria to obtain the bio-broken product of P. spp., extracting it by dynamic warm soaking method for 16 hours, and obtaining the extract; firstly, using alcohol extraction and water precipitation method to remove fat-soluble impurities such as chlorophyll , and then remove water-soluble impurities such as sugars by water extraction and alcohol precipitation, and preliminarily separate and purify the crude extract of P. candidum to obtain the crude extract, the weight of which is 5.5-6% of the weight of the raw material.

[0035] The bacterial species used in the enzymolysis of the combined bacteria is the spore of the Dutch strain, which is derived from the fermentation powder of Jingde Pan Chicken and produced by Jiangxi ...

Embodiment 2

[0077] Example 2 Evaluating the effect of P. radicis on promoting the healing of rat skin cut models

[0078] At present, the in vivo models commonly used in the world to evaluate the effect of promoting skin healing mainly include rat skin cut model, excision wound model, dead space wound model (dead space wound model) and burn model.

[0079] The present invention takes Pyrrha officinalis and its isolated products as research objects, and experiments are carried out with rat skin cuts and excision wounds as research models, laying a working foundation for basic research on substances of P.

[0080] experimental method:

[0081] 1) 15 rats were randomly divided into 3 groups, namely the blank group, the nitrofurazone group and the Roropetalum officinalis group, and each rat was reared in a single cage to prevent them from biting each other's wounds;

[0082] 2) After three days of adaptive feeding, 3% sodium pentobarbital was anesthetized, the back was depilated, and a wound...

Embodiment 3

[0087] Example 3 Evaluation of the effect of P. radicis on promoting the healing of the rat skin excision wound model

[0088] Operation method:

[0089] 1) 15 rats were randomly divided into 3 groups, namely the blank group, the nitrofurazone group and the Roropetalum officinalis group, and each rat was reared in a single cage to prevent them from biting each other's wounds;

[0090] 2) After three days of adaptive feeding, 3% sodium pentobarbital anesthetized, the back was depilated, and a total skin excision of about 400mm2 in size (without damaging the fascia layer) was carried out on the upper part of the back spine of each rat. Put a ruler on the same plane as the wound as a reference for the actual size, take pictures with a digital camera, and record the initial size of the wound;

[0091] 3) Apply medicine to the wound after operation: apply 2% sodium alginate to the wound of the blank group, 1% nitrofurazone to the wound of the nitrofurazone group, and 1% fenugreek ...

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Abstract

The invention relates to application of white flower loropetalum chinense in preparing healing medicine, which adopts two internationally used internal models of an incision wound model and an excision wound model of rat skins to research healing effect of white flower loropetalum chinense coarse extractives. Tests show that healing speed of the rat skins can be obviously promoted, wound healing time is shortened, wound healing strength is enhanced, and regeneration of cells and vessels at position of wounds is promoted. The application of the white flower loropetalum chinense in preparing the healing medicine also finds that when the white flower loropetalum chinense coarse extractives are further separated and extracted, ingredients of petroleum ether layers, ethyl acetate layers and n-butyl alcohol layers are strong in wound healing effect.

Description

Technical field: [0001] The invention relates to the application of the extract of loropetalum alba in preparation of callus medicine. Background technique: [0002] Skin trauma is a common health problem for human beings. It can be roughly divided into two types: open and closed. Open wounds include abrasions, lacerations, shots, cuts, excisions, and surgical injuries. Closed wounds include contusions. , crush injury, sprain, concussion injury, joint dislocation and subluxation, closed fracture, closed visceral injury, etc. [0003] The main function of the skin is to act as a natural barrier to prevent the loss of extracellular fluids and protect the body from external environmental disturbances and infringements. Skin trauma is a common health problem that has existed since ancient times and has a high incidence. If not handled properly, it can cause serious problems and even death. Therefore, finding drugs that promote wound healing is one of the oldest and most import...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61P17/02
Inventor 刘浩元李晓滨曲淑娟
Owner 江西徳宇集团
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