Electron capture dissociation apparatus and related methods

Abstract

An electron capture dissociation apparatus comprises ion guide electrodes, an electron emitter, and an electron control device. The ion guide electrodes are arranged along a central axis and spaced circumferentially to circumscribe an interior space extending along the central axis. The electron emitter is disposed outside the interior space. The electron control device is configured for focusing an electron beam from the electron emitter toward the central axis, along a radial electron beam direction between two of the ion guide electrodes, and for decelerating the electron beam in a DC decelerating field of adjustable voltage potential directed along the electron beam direction.

Description

[0001] Cross References to Related Applications [0002] This patent application claims the benefit of US Patent Application No. 12 / 547,358, filed August 25, 2009. technical field [0003] The present invention generally relates to fragmentation of ions by electron capture dissociation, particularly in ion traps driven by electric fields in the absence of magnetic fields. Background technique [0004] Ion traps are commonly used in mass spectrometers (MS) as a means of controlling and spatially confining ion motion for various purposes. The design and operation of various types of ion traps and associated mass spectrometers are well known to those skilled in the art and thus need not be described in detail herein. One common class of ion traps is the Penning trap or ion cyclotron resonance (ICR) cell, sold commercially as a Fourier transform mass spectrometer (FTMS). Penning traps use an electrode arrangement to apply fixed magnetic and electric fields to confine ions rad...

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Problems solved by technology

Thus, while SORI will generate an increase in internal energy due to ion-molecule collisions, the ions will not be positioned in a way that reacts with the electrons in the trapping cell

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