Catalyst used in preparation of chiral amino alcohol, preparation method and application

Abstract

The invention discloses a catalyst used in preparation of chiral amino alcohol, a preparation method and application. According to the catalyst used in preparation of the chiral amino alcohol, copper, transition metal and rare earth oxide are used as active ingredients, and aluminum oxide is used as a carrier, wherein the transition metal is one or mixtures of two or more than two of nickel oxide, zinc oxide, molybdenum oxide or tungsten oxide; and the rare earth oxide is one or mixtures of two or more than two of cerium oxide, lanthanum oxide, samarium oxide, gadolinium oxide or praseodymium oxide. According to the preparation method of the catalyst, an improved coprecipitation method is adopted. The obtained catalyst used in preparation of the chiral amino alcohol is hydrogenated and reduced and then used for catalytic hydrogenation of the chiral amino acid ester to prepare the chiral amino alcohol, has the advantages of high catalytic activity and product selectivity, easiness for separation of a product and low catalyst cost, and is extremely suitable for industrial production. The catalyst can also be used as a hydrogenolysis catalyst of compounds such as glycerol.

Description

technical field [0001] The invention belongs to the field of chemistry, and relates to a catalyst for preparing chiral amino alcohol and a preparation method. Specifically, it relates to a catalyst with copper, transition metal and rare earth oxides as active components and alumina as a carrier. The catalyst can catalyze the hydrogenation of chiral amino acid esters to prepare chiral amino alcohols, and can obtain higher product yield. Background technique [0002] Chiral amino alcohol compounds contain N atoms and O atoms with strong coordination ability, and can form complexes with various elements, which can control the coordination number and stereo configuration more conveniently, improve the rigidity of the complexes, and thus can catalyze And induce various types of asymmetric organic reactions, making it a very important and efficient asymmetric synthesis catalyst combined with metals. At the same time, the structure of amino alcohol is ubiquitous in many biologica...

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a kind of catalyst and preparation method for the catalytic hydrogenation of chiral amino acid ester to produce chiral aminoalcohol, to overcome the deficiencies of high production cost in the prior art, the catalyst preparation process of the present invention is simple, The source of raw materials is wide, and the catalytic hydrogenation of chiral amino acid esters to produce chiral amino alcohols has good activity. It can replace the existing noble metal catalysts and realize commercial applications.