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Transmucosal medicine conveying device with electric driving seepage enhancing effect and transmucosal medicine conveying method

An electric drive, transmucosal technology, applied in the direction of drug devices, other medical devices, etc., can solve the problem of wasting drugs

Inactive Publication Date: 2012-08-22
PALO ALTO RES CENT INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, large amounts of drug can be wasted using conventional administration techniques

Method used

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  • Transmucosal medicine conveying device with electric driving seepage enhancing effect and transmucosal medicine conveying method
  • Transmucosal medicine conveying device with electric driving seepage enhancing effect and transmucosal medicine conveying method
  • Transmucosal medicine conveying device with electric driving seepage enhancing effect and transmucosal medicine conveying method

Examples

Experimental program
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Effect test

Embodiment Construction

[0019] A transmucosal drug delivery device for intralumenal deployment is provided. As used herein, the term "intraluminal" means placement within a body cavity, passage, duct, etc. having a mucosal tissue wall. The term includes, but is not limited to, intravaginal, intrauterine, and intragastrointestinal sites. Insertion or placement of the device within the lumen is typically maintained during delivery of at least one or more doses of drug. The implanted device can be withdrawn from the lumen as needed, for example between delivery of individual doses, after delivery of several doses of drug, or after completion of a series of multi-dose treatments. The device can be left in place until the drug payload is consumed.

[0020] As used herein, the terms "mucosal tissue" and "mucosa" are used interchangeably.

[0021] In some embodiments, a transmucosal drug delivery device includes (i) a housing configured to allow placement within a lumen, (ii) one or more reservoirs for c...

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Abstract

The invention discloses a transmucosal medicine conveying device with an electric driving seepage enhancing effect and a transmucosal medicine conveying method. The device can comprise a case, a medicine distribution part and an electric driving part, wherein the case is configured and is used for placing human or animal subjects in a cavity, the medicine distribution part is used for accommodating at least one kind of medicine, and the electric driving part is configured to a state that when the human or animal subjects are placed in the cavity, at least one region of a mucosa blocking layer adjacent to the case is damaged in the selected time. The device can be operated so that the medicine is distributed to the region of the mucosa blocking layer damaged by the electric driving part.

Description

technical field [0001] Embodiments disclosed herein relate to implantable medical devices, and more particularly to devices and methods for transmucosal delivery of drugs to a patient. Background technique [0002] Transmucosal drug delivery is an area of ​​interest because it is possible to deliver systemically acting drugs with high relative bioavailability by avoiding first-pass metabolism effects, possibly to the target of interest. The therapeutic agent is delivered locally at the site, and the route of administration is convenient. Some possible sites for transmucosal drug delivery include oral, nasal, vaginal and rectal routes of administration. [0003] There are a number of challenges associated with transmucosal drug delivery, especially the transmucosal delivery of macromolecules including certain amino acid sequences. Enzymes present in fluid secreted by mucosal tissues break down certain amino acids. The types of enzymes presented by mucosal tissue vary accor...

Claims

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Application Information

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IPC IPC(8): A61M31/00A61M37/00
Inventor S.尤兰德E.彼得斯S.H.Y.王
Owner PALO ALTO RES CENT INC
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