Unlock instant, AI-driven research and patent intelligence for your innovation.

Anti-inflammatory agent for oral application, and anti-inflammatory peptide for oral application

A technology for functional agents and inflammatory cytokines, which can be applied in the direction of anti-inflammatory agents, peptides, tripeptide components, etc., and can solve problems such as possibility limitation

Inactive Publication Date: 2014-09-17
FUJI OIL CO LTD +1
View PDF8 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the possibilities for use in food materials are limited

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Anti-inflammatory agent for oral application, and anti-inflammatory peptide for oral application
  • Anti-inflammatory agent for oral application, and anti-inflammatory peptide for oral application
  • Anti-inflammatory agent for oral application, and anti-inflammatory peptide for oral application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1 and comparative Embodiment 1 and 2

[0064] "Example 1 and Comparative Examples 1 and 2"

[0065] "Prevention and Treatment of Ulcerative Colitis"

[0066]First, 18 pigs at the age of 3 days and 5 days were divided into 3 groups and they were bred for 3 days. Subsequently, the groups were designated as a test group (Example 1 and Comparative Example 1) and a control group (Comparative Example 2) and 1.25 g of dextran sulfate / kg body weight was supplied as drinking water for 5 days (DSS treatment) . Subsequently, 250 mg of peptide composition 1 / kg body weight was fed for 5 days in Example 1, 250 mg of peptide composition 2 / kg body weight was fed for 5 days in Comparative Example 1, and feeding corresponding to Alanine for the nitrogen content of the peptide. Then, intestinal cells were collected during dissection and cytokines were measured. Comparative Example 2 corresponds to a comparative example. (Dextran sulfate is a substance that induces enteritis. International J. of Colorectal Disease, 15, 144-160 (2...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The object of the present invention is to provide a composition having an anti-inflammatory function effective for inflammatory diseases such as inflammatory bowel disease and a treatment method using the composition. The present invention relates to: an oral anti-inflammatory functional agent as soybean peptide and a treatment method using the anti-inflammatory functional agent, wherein the molecular weight of the soybean peptide is 500 or less, and the fraction other than free amino acids is more than 40% by weight and free The amino acid content is 7% by weight or less. Moreover, the present invention relates to: a novel tripeptide with anti-inflammatory function, which comprises the amino acid sequence of phenylalanine-leucine-valine or valine-proline-tyrosine; Oral anti-inflammatory composition, medicament and feed with peptide as active ingredient; and method of treating inflammatory bowel disease using said novel peptide.

Description

technical field [0001] The present invention relates to peptides with anti-inflammatory function. The present invention also relates to novel tripeptides Phe-Leu-Val and Val-Pro-Tyr with anti-inflammatory function. technical background [0002] Patent Document 1 is an application related to a peptide demonstrating an anti-inflammatory function. This application describes a number of Arg-containing dipeptides and tripeptides, and also describes various physiological actions other than anti-inflammatory functions. However, these are all premised on synthetic production and it is difficult to say that safety is sufficiently established. Additionally, Phe-Leu-Val and Val-Pro-Tyr are not described. [0003] Patent Document 2 is an application that does not directly describe an anti-inflammatory function, but describes a food-derived component that acts on gastrointestinal ulcers, and this effect is also confirmed in the present invention. However, this only describes the acti...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/00A61P1/00A61P1/12A61P29/00A61P43/00C07K5/087A23L33/17A23L33/18A61K38/06A61P1/04
CPCA61K38/00C07K5/0808C07K5/0812A61P1/00A61P1/04A61P1/12A61P29/00A61P43/00
Inventor 峯芳德伊吹昌久长谷川芳则
Owner FUJI OIL CO LTD