Assessment method for prostatic cancer onset risk gene and diagnostic kit

A diagnostic kit and prostate cancer technology, applied in the biological field, can solve the problems of unclear cause of prostate cancer and slow growth of prostate cancer

Inactive Publication Date: 2012-09-19
SHENYANG MEDICAL COLLEGE
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Problems solved by technology

Prostate cancer usually grows slowly, and patients often have obvious symptoms or signs after several years of onset. Therefore, timely detec

Method used

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  • Assessment method for prostatic cancer onset risk gene and diagnostic kit
  • Assessment method for prostatic cancer onset risk gene and diagnostic kit
  • Assessment method for prostatic cancer onset risk gene and diagnostic kit

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Experimental program
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Embodiment Construction

[0020] The T-G-C-C-T-G haplotype composed of SNP10-11-13-15-22-23 in the OPN gene will significantly increase the risk of prostate cancer (P=3.64×10 -6 ), the G-T-C-C-T-G haplotype will significantly reduce the risk of prostate cancer (P=0.0185).

[0021] Individuals with the G-T-C-A-A haplotype composed of SNP35-49-59-62-64 in the OPN gene will significantly reduce the risk of prostate cancer (P=0.0069).

[0022] SNP35-49-59 in the OPN gene constitutes the A-C-T haplotype, the incidence of prostate cancer is significantly increased (P=0.002), and the probability of prostate hyperplasia is increased in the G-T-C haplotype (P=0.002).

[0023]

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Abstract

The invention discloses an assessment method for early assessing the onset risk of prostatic cancer by using polymorphism of an osteopontin gene and a diagnostic kit. The invention belongs to biotechnology invention and is mainly characterized in that genetic typing is carried out on a haplotype comprising SNP (Single Nucleotide Polymorphism) (10), SNP (11), SNP (13), SNP (15), SNP (22) rs2853749 and SNP (23) rs2853750 and haplotype comprising SNP (35) rs6532039, SNP (49) rs4754 and SNP (59) rs1126616 in osteopontin (OPN) gene, so that the onset risk of the prostatic cancer can be assessed and early diagnosis and differential diagnosis are realized. The assessment method and the diagnostic kit disclosed by the invention are suitable for onset risk evaluation and early diagnosis of physical examination people and individuals with cancer family history and examination will or can be used for differential diagnosis of the prostatic cancer and benign prostatic hyperplasia.

Description

technical field [0001] The invention relates to a biotechnology invention, a method and a diagnostic kit for early assessment of prostate cancer risk by using Osteopontin (OPN) gene polymorphism. Background technique [0002] Prostate cancer is the most common malignant tumor in men, accounting for the second cause of cancer death in men, accounting for about 40% of all male cancer patients. In recent years, with the aging of the population and the improvement of living conditions, the incidence has increased significantly. Prostate cancer usually grows slowly, and patients often have obvious symptoms or signs after several years of onset. Therefore, timely detection and early treatment are the key to the diagnosis and treatment of prostate cancer. However, the cause of prostate cancer is still unclear. [0003] The completion of the Human Genome Project brought our understanding of the molecular mechanism of cancer into a new stage. Gene polymorphism (single nucleotide po...

Claims

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Application Information

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IPC IPC(8): C12Q1/68
Inventor 高兵芦秀丽邓智先刘健王有亮刘泽辉朱志强
Owner SHENYANG MEDICAL COLLEGE
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