Microfluidic reactor

A technology of microfluidic reactors and reaction pools, applied in chemical instruments and methods, chemical/physical/physicochemical processes, chemical/physical processes, etc., can solve problems such as reaction pools that cannot meet requirements, and achieve wide applicability, assembly Simple, even force level effect

Active Publication Date: 2012-10-03
CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in some experiments where the reaction cell needs to be placed horizontally, this type of reaction cell cannot meet the requirements

Method used

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Experimental program
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Embodiment 1

[0037] See attached Picture 1-1 0, a microfluidic reactor comprising: a base 10, a reaction pool plate 20, a slide 30, a rubber ring 40 and a screw cover 50, the reaction pool plate 20 is placed on the base 10, and the slide 30 The cover is on the reaction pool plate 20 , the three constitute a complete reaction chamber, and the rubber ring 40 is buffered and the screw cover 50 is horizontally pressed against the glass slide to seal the reaction chamber.

[0038]The upper and lower surfaces of the reaction pool plate 20 manufactured by using PDMS through grinding tools are flat and smooth, with a length of 60 mm, a width of 25 mm, and a thickness of 1 mm. No bottom, no cover, symmetrical shape, wide in the middle, narrow at both ends, similar to fusiform. Two ends of the reaction pool 24 are circular ports, one is a liquid inlet hole 22, and the other end is a liquid outlet hole 23, both of which have a radius of 0.9mm. The center of the shape of the reaction pool is symmet...

Embodiment 2

[0048] The structure of embodiment 2 is identical with embodiment 1, and concrete structural parameter is:

[0049] ∠ABC, ∠A′B′C′, ∠BAD, ∠B′A′D′ are 135 degrees. The straight line AB and the straight line A'B' are 2 mm long, and the distance between the straight line AB and the straight line A'B' is 2 mm. The width CC' and DD' of the liquid inlet or outlet of the reaction pool are 0.2 mm, and the length of the rectangular channel is 0.3 mm. The total area T of the reaction pool is about 7mm 2 . Fluent simulation is carried out with the inlet velocity 5mm / s, and the uniform area A obtained with the average velocity between 0.46-0.92mm / s is 5.4mm 2 , the uniformity rate R (A / T) is 77.14%; compared with the corresponding conventional diamond-shaped pool, the total area T of the reaction pool is 6.1mm 2 , the uniform area A is 4mm 2 , The uniform rate R is 65.57%. In this embodiment, the uniformity rate of the shuttle-shaped reaction cell is relatively large, indicating that...

Embodiment 3

[0051] The structure of embodiment 3 is identical with embodiment 1, and concrete structural parameter is:

[0052] ∠ABC, ∠A′B′C′, ∠BAD, ∠B′A′D′ are 165 degrees. The length of the straight line AB and the straight line A'B' is 60mm, the distance between the straight line AB and the straight line A'B' is 50mm, the width CC' and DD' of the liquid inlet or outlet of the reaction pool are 6mm, and the length of the rectangular channel is 9mm. The total area T of the reaction pool is about 8979mm 2 . Fluent simulation is carried out at the entrance speed of 50mm / s, and the uniform area A with the average speed between 7.2-10.9mm / s is 6079mm 2 , the uniformity rate R (A / T) is 67.70%; compared with the corresponding conventional diamond-shaped pool, the total area T of the reaction pool is 7706mm 2 , the uniform area A is 4210mm 2 , The uniform rate R is 54.63%. In this embodiment, the uniformity rate of the shuttle-shaped reaction cell is relatively large, indicating that the ...

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Abstract

The invention discloses a microfluidic reactor which comprises a base, a reaction pool plate, a slide, a rubber ring and a spiral cover. The base, the reaction pool plate and the slide form a complete reaction chamber; the spiral cover is horizontally pressed on the slide through the buffering of the rubber ring to seal the reaction chamber. Due to the bionic design of a fusiform reaction pool on the reaction pool plate, the flow field is distributed uniformly during the flow of the fluid in the reaction chamber, and no fluid is left during discharge. The microfluidic reactor can not be affected by the placement azimuth and can be also used for the reaction needing temperature controlling and lighting. The microfluidic reactor can be widely used for the microfluidic reaction experiments in various fields including the biological field, the chemical field, the medical field and the like.

Description

technical field [0001] The invention discloses a microfluidic reactor, in particular to a microfluidic reactor with uniform flow field distribution, no residual liquid and temperature control. The invention belongs to the technical field of microfluidic biochemical reaction instrument preparation. Background technique [0002] As the main place of microfluidic biochemical reaction, the performance of microfluidic reactor directly affects the result of the reaction. In a complete biochemical reaction, it is generally necessary to carry out a multi-step reaction in which multiple reagents are alternately filled in the same reaction chamber, but when a small amount of liquid enters the reaction chamber, the flow rate changes due to the change of the cross-sectional area, and the flow in the reaction chamber When the fluid is filled into the reaction chamber, it will be subject to frictional resistance and some capillary siphon effects, which will easily cause uneven flow veloc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J19/00
Inventor 刘正春王宏银吴灶全邬燕琪杨飞鹏徐友志
Owner CENT SOUTH UNIV
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