Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Sensor chip, preparation method and use thereof

A technology for sensor chips and applications, which is applied in the field of sensor chips and its preparation, can solve the problems of poor reusability of sensor chips, harsh detection environment requirements, and high cost, and achieve high sensitivity, simple and convenient operation, and fast response fast effect

Inactive Publication Date: 2012-10-17
BEIJING INSTITUTE OF TECHNOLOGYGY
View PDF2 Cites 12 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The research on immunoassay is one of the fields with the earliest application practice, the widest application range and the most complete development of surface plasmon resonance sensing technology. Insurmountable shortcomings such as poor performance limit the application of surface plasmon resonance technology in actual detection

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Sensor chip, preparation method and use thereof
  • Sensor chip, preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] A sensing chip, the sensing chip is composed of a glass substrate, a gold film layer, a monomolecular alkyl chain layer and a molecularly imprinted polymer film, and from bottom to top are the glass substrate, gold film layer, alkyl Monomolecular chain layers and molecularly imprinted polymer films.

[0039] The gold film layer and the monomolecular alkyl chain layer are combined, and the structural formula is Au-(CH 2 ) 11 CH 3 ;

[0040] The molecularly imprinted polymer film is prepared from template molecules, functional monomers, cross-linking agents, porogens, and photoinitiators through photopolymerization to obtain a molecularly imprinted polymer film containing template molecules, and then the progesterone is eluted with an eluent The template molecule is obtained, wherein the template molecule is progesterone, the functional monomer is methacrylic acid, the crosslinking agent is ethylene glycol dimethacrylate, the porogen is acetonitrile, and the photoiniti...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention relates to a sensor chip, a preparation method and a use thereof, and belongs to the field of hormone detection analysis. The sensor chip sequentially comprises a glass substrate, a gold film layer, a single molecule alkyl chain layer and a progesterone molecule imprinting polymer film from bottom to top. The preparation method comprises: plating a gold film on a glass substrate, forming a single molecule alkyl chain layer on the gold film, and forming a molecule imprinting polymer film on the single molecule alkyl chain layer to obtain the sensor chip, wherein the molecule imprinting polymer film only provides a response for progesterone molecule. The sensor chip can be used for a surface plasmon resonance sensor to detect progesterone content, wherein the sensor chip absorbs progesterone molecules in a sample during detecting, the resonance angle is changed, and the resonance angle change value is proportional to the sample concentration, such that the progesterone content in the sample can be quantitatively detected based on the resonance angle change. According to the present invention, the molecule imprinting technology is adopted, and the prepared sensor chip provides characteristic of sensitivity, rapidness, accuracy and simpleness during progesterone detection.

Description

technical field [0001] The invention relates to a sensor chip and its preparation method and application. Specifically, the sensor chip is prepared by using molecular imprinting (Molecular Imprinting) technology, which can be applied to the surface plasmon resonance sensor (Surface Plasmon Resonance Sensor) for detecting progesterone (Progesterone, also known as progesterone) content, belonging to the field of hormone detection and analysis. Background technique [0002] Progesterone is a natural progestin secreted by the corpus luteum of the ovary. It has a significant morphological effect on the estrogen-stimulated endometrium in vivo and is necessary to maintain pregnancy. When the human body is stimulated by progesterone in the external environment, it will cause endocrine disorders in the body. Therefore, progesterone in the environment is often listed as an endocrine-disrupting compound (endocrine-disrupting compound, EDC), which has attracted extensive attention from...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): G01N21/41C08F222/14C08F220/56C08F222/38C08F212/36C08F220/06C08F220/28C08J9/28C08J9/26
Inventor 韦天新张庆文刘兰兰裴芳誉
Owner BEIJING INSTITUTE OF TECHNOLOGYGY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com