Sensor chip, preparation method and use thereof

A technology for sensor chips and applications, which is applied in the field of sensor chips and its preparation, can solve the problems of poor reusability of sensor chips, harsh detection environment requirements, and high cost, and achieve high sensitivity, simple and convenient operation, and fast response fast effect
CN102735647AInactive Publication Date: 2012-10-17BEIJING INSTITUTE OF TECHNOLOGYGY
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
BEIJING INSTITUTE OF TECHNOLOGYGY
Publication Date
2012-10-17
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention relates to a sensor chip, a preparation method and a use thereof, and belongs to the field of hormone detection analysis. The sensor chip sequentially comprises a glass substrate, a gold film layer, a single molecule alkyl chain layer and a progesterone molecule imprinting polymer film from bottom to top. The preparation method comprises: plating a gold film on a glass substrate, forming a single molecule alkyl chain layer on the gold film, and forming a molecule imprinting polymer film on the single molecule alkyl chain layer to obtain the sensor chip, wherein the molecule imprinting polymer film only provides a response for progesterone molecule. The sensor chip can be used for a surface plasmon resonance sensor to detect progesterone content, wherein the sensor chip absorbs progesterone molecules in a sample during detecting, the resonance angle is changed, and the resonance angle change value is proportional to the sample concentration, such that the progesterone content in the sample can be quantitatively detected based on the resonance angle change. According to the present invention, the molecule imprinting technology is adopted, and the prepared sensor chip provides characteristic of sensitivity, rapidness, accuracy and simpleness during progesterone detection.
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Description

technical field

[0001] The invention relates to a sensor chip and its preparation method and application. Specifically, the sensor chip is prepared by using molecular imprinting (Molecular Imprinting) technology, which can be applied to the surface plasmon resonance sensor (Surface Plasmon Resonance Sensor) for detecting progesterone (Progesterone, also known as progesterone) content, belonging to the field of hormone detection and analysis. Background technique

[0002] Progesterone is a natural progestin secreted by the corpus luteum of the ovary. It has a significant morphological effect on the estrogen-stimulated endometrium in vivo and is necessary to maintain pregnancy. When the human body is stimulated by progesterone in the external environment, it will cause endocrine disorders in the body. Therefore, progesterone in the environment is often listed as an endocrine-disrupting compound (endocrine-disrupting compound, EDC), which has attracted extensive attention from...

Claims

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